Evidence map›Paper›PMID 36334826›Full record

ArticleEnvironmental research2023

Effects of long-term average temperature on cardiovascular disease hospitalizations in an American elderly population.

Jochem O Klompmaker, Francine Laden, Peter James, M Benjamin Sabath, Xiao Wu, Joel Schwartz, Francesca Dominici, Antonella Zanobetti, Jaime E Hart

Open access · hybridAbstract read
In one paragraph

Article in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  10. Effects of PMFrontiers in public health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jochem O KlompmakerDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jklompmaker@hsph.harvard.edu.
Francine LadenDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Peter JamesDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts 02115, USA; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
M Benjamin SabathDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Xiao WuDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Joel SchwartzDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts 02115, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Francesca DominiciDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Antonella ZanobettiDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts 02115, USA.
Jaime E HartDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Harvard University · USBrigham and Women's Hospital · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
National Cohort Studies of Alzheimer's Disease, Related Dementias and Air PollutionR01AG066793 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2020 to 2025
$4.2M
Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular HealthR01HL150119 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAMES, PETER · 2020 to 2024
$3.9M
Environmental Health Disparities in an Older PopulationR01MD012769 · NIMHD · YALE UNIVERSITY · PI BELL, MICHELLE L · 2017 to 2021
$3.9M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health StudiesR01ES030616 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DOMINICI, FRANCESCA, KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2020 to 2024
$3.1M
Disease Outcomes iN Older adults under extreme Heat, AiR pollution and Medication use (DO-NO-HARM)R01AG060232 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI SETOGUCHI IWATA, SOKO · 2019 to 2023
$3.0M
The confluence of extreme heat cold on the health and longevity of an Aging Population with Alzheimers and related DementiaRF1AG074372 · NIA · HARVARD MEDICAL SCHOOL · PI DOMINICI, FRANCESCA, ESTIRI, HOSSEIN · 2022 to 2023
$2.6M
Cardiovascular Health and Air Pollution: A National StudyR01ES024332 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2015 to 2018
$2.5M
Evidence to improve heat warning effectiveness in reducing morbidity and mortality.R01ES029950 · NIEHS · BROWN UNIVERSITY · PI WELLENIUS, GREGORY A · 2019 to 2022
$2.5M
Short and long-term consequences of wildfires for Alzheimer's disease and related dementias.RF1AG071024 · NIA · UNIVERSITY OF WASHINGTON · PI CASEY, JOAN A · 2021 to 2022
$2.4M
NHLBI NIH HHS R01 HL150119NIA NIH HHS R01 AG060232NIA NIH HHS R01 AG066793NIA NIH HHS RF1 AG071024NIA NIH HHS RF1 AG074372NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES024332NIEHS NIH HHS R01 ES026217NIEHS NIH HHS R01 ES028033NIEHS NIH HHS R01 ES029950NIEHS NIH HHS R01 ES030616NIEHS NIH HHS T32 ES007069NIMHD NIH HHS R01 MD012769
6 · The paper itself

Abstract

backgroundShort-term exposure to high or low temperatures is associated with increased mortality and morbidity. Less is known about effects of long-term exposure to high or low temperatures. Prolonged exposure to high or low temperatures might contribute to pathophysiological mechanisms, thereby influencing the development of diseases. Our aim was to evaluate associations of long-term temperature exposure with cardiovascular disease (CVD) hospitalizations.

methodsWe constructed an open cohort consisting of all fee-for-service Medicare beneficiaries, aged ≥65, living in the contiguous US from 2000 through 2016 (∼61.6 million individuals). We used data from the 4 km Gridded Surface Meteorological dataset to assess the summer (June-August) and winter (December-February) average daily maximum temperature for each year for each zip code. Cox-equivalent Poisson models were used to estimate associations with first CVD hospitalization, after adjustment for potential confounders. We performed stratified analyses to assess potential effect modification by sex, age, race, Medicaid eligibility and relative humidity.

resultsHigher summer average and lower winter average temperatures were associated with an increased risk of CVD hospitalization. We found a HR of 1.068 (95% CI: 1.063, 1.074) per IQR increase (5.2 °C) for summer average temperature and a HR of 1.022 (95% CI: 1.017, 1.028) per IQR decrease (11.7 °C) for winter average temperature. Positive associations of higher summer average temperatures were strongest for individuals aged <75 years, Medicaid eligible, and White individuals. Positive associations of lower winter average temperatures were strongest for individuals aged <75 years and Black individuals, and individuals living in low relative humidity areas.

conclusionsLiving in areas with high summer average temperatures or low winter average temperatures could increase the risk of CVD hospitalizations. The magnitude of the associations of summer and winter average temperatures differs by demographics and relative humidity levels.

Indexed as

Cardiovascular DiseasesAgedHospitalizationHumansMedicareSeasonsTemperatureUnited StatesCardiovascular diseaseClimateTemperature

Identifiers

PMID36334826
PMCPMC10236856
OpenAlexW4307982809

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.