ArticleKidney international2023
A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury.
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Article in Kidney international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
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Who cites it
63 citing papers in PubMed, 68 citations in OpenAlex.
- Metabolic control of macrophages in coronavirus disease 2019.Virulence · 2026Review
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- D4F-Functionalized Ceria Nanozyme-CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Inflammation as a therapeutic target to improve kidney and cardiovascular outcomes.Nature reviews. Nephrology · 2026Review
- Insights from integrative spatial transcriptomics in sepsis-associated acute kidney injury.Nature reviews. Nephrology · 2026Review
- Single-cell RNA sequencing and spatial transcriptomics in the discovery of kidney disease potential biomarkers: a narrative review.BMC nephrology · 2026Review
- Ginsenoside Rb1 mitigates senescence-associated hepatic steatosis in mice through enhanced lysine degradation.Journal of ginseng research · 2026Article
- Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis.The Journal of clinical investigation · 2026Article
- Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation.The American journal of pathology · 2026Article
- CX3CR1-mediated immune networks in sepsis: implications for precision therapy.Cell death discovery · 2026Review
- Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation.Signal transduction and targeted therapy · 2026Article
- Predicting Macrophage Spatial Localization from Single-Cell Transcriptomes to Uncover Disease Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cell-cell crosstalk in kidney health and disease.Nature reviews. Nephrology · 2026Review
- Metabolic phenotyping of sepsis in large multicenter cohorts: identification of a reproducible high-risk subgroup.Lipids in health and disease · 2026Article
- SUMOylation protects against sepsis-associated acute kidney injury by stabilizing IκBα.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- A macrophage-endothelial cell axis in kidney diseases.International urology and nephrology · 2026Review
- Interaction networks of macrophage glycolysis and inflammation in sepsis: mechanisms and therapeutic potential.Frontiers in immunology · 2026Review
- Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes.International journal of molecular medicine · 2026Article
- Therapeutic effect of Yupingfeng powder and its bioactive metabolites on renal diseases.Frontiers in pharmacology · 2026Review
- Cinnamaldehyde attenuates LPS-induced acute kidney injury by inhibiting ferroptosis via the Gsk3β/Nrf2/Gpx4 pathway.American journal of translational research · 2026Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Jamie R PrivratskyCenter for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA; Division of Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
Shintaro IdeDivision of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Yanting ChenCenter for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
Hiroki KitaiDivision of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Jiafa RenDivision of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Helene FradinDuke Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, USA.
Xiaohan LuDivision of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Tomokazu SoumaDivision of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Steven D CrowleyDivision of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Durham VA Medical Center, Durham, North Carolina, USA. Electronic address: steven.d.crowley@duke.edu.
Duke Medical Center · USDuke University Hospital · USDurham VA Medical Center · US
Funding
Targeting Renal Tubular Epithelial Progenitors in AKI to CKD transitionR01DK123097 · NIDDK · DUKE UNIVERSITY · PI SOUMA, TOMOKAZU · 2020 to 2024
$2.2MThe interleukin-1 receptor regulates crosstalk between myeloid and renal tubular cells in hypertensionR01DK118019 · NIDDK · DUKE UNIVERSITY · PI CROWLEY, STEVEN D · 2019 to 2022
$1.7MNovel mitochondrial protective properties of annexin A1R01DK131065 · NIDDK · DUKE UNIVERSITY · PI PRIVRATSKY, JAMIE R · 2021 to 2025
$1.6MThe Role of the IL-1 Receptor in the AKI to CKD transitionK08GM132689 · NIGMS · DUKE UNIVERSITY · PI PRIVRATSKY, JAMIE R · 2019 to 2023
$900kThe role of the M1 macrophage response in the progression of chronic kidney diseaseI01BX000893 · VA · DURHAM VA MEDICAL CENTER · PI Steven D Crowley · 2012 to 2026
–BLRD VA I01 BX000893NIDDK NIH HHS R01 DK118019NIDDK NIH HHS R01 DK123097NIDDK NIH HHS R01 DK131065NIGMS NIH HHS K08 GM132689
Abstract
The most common cause of acute kidney injury (AKI) in critically ill patients is sepsis. Kidney macrophages consist of both F4/80
Indexed as
Acute Kidney InjuryCOVID-19SepsisAnimalsEndothelial CellsInterleukin-6KidneyMacrophagesMiceMice, Inbred C57BLReceptors, Interleukin-1Interleukin-6Receptors, Interleukin-1acute kidney injurycytokinesendotheliummacrophagessepsis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.