Evidence map›Paper›PMID 36334323›Full record

ArticleJournal of biomechanics2022

Increases in hydraulic conductance and solute permeability in a mouse model of ascending thoracic aortic aneurysm.

Christie L Crandall, Sean Y Kim, Jacob Rother, Vivian S Lee, Robert P Mecham, Jessica E Wagenseil

Open access · greenAbstract read
In one paragraph

Article in Journal of biomechanics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Transport across the thoracic aortic wall: implications for aneurysm pathobiology, diagnosis, and treatment.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christie L CrandallDepartment of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, United States.
Sean Y KimDepartment of Biomedical Engineering, Saint Louis University, St. Louis, MO, United States.
Jacob RotherDepartment of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, United States.
Vivian S LeeDepartment of Cell Biology and Physiology, Washington University, St. Louis, MO, United States.
Robert P MechamDepartment of Cell Biology and Physiology, Washington University, St. Louis, MO, United States.
Jessica E WagenseilDepartment of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, United States. Electronic address: jessica.wagenseil@wustl.edu.
Washington University in St. Louis · USSaint Louis University · US

Funding

ASSEMBLY OF LUNG ELASTINR37HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 2000 to 2009
$4.1M
ASSEMBLY OF LUNG ELASTINR01HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 1995 to 2019
$3.6M
Complementary animal and computational models for biomarker identification in ascending thoracic aortic aneurysmR01HL164800 · NHLBI · WASHINGTON UNIVERSITY · PI VICTOR H BAROCAS, Jessica Wagenseil · 2022 to 2026
$3.2M
Tspan14 expression and function in cardiovascular diseaseR00HL163411 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Vivian Lee-Kim · 2024 to 2026
$696k
Tspan14 expression and function in cardiovascular diseaseK99HL163411 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE-KIM, VIVIAN · 2022 to 2023
$258k
NHLBI NIH HHS K99 HL163411NHLBI NIH HHS R00 HL163411NHLBI NIH HHS R01 HL053325NHLBI NIH HHS R01 HL164800NHLBI NIH HHS R37 HL053325
6 · The paper itself

Abstract

Large elastic arteries, such as the aorta, contain concentric layers of elastic laminae composed mainly of the extracellular matrix protein elastin. The structure of the elastic laminae could affect transmural mass transport and contribute to aortic disease progression. We studied the effects of a genetic mutation (Lox

Indexed as

Aortic Aneurysm, ThoracicMicroscopyAnimalsMiceDiffusionElastinLysyl oxidaseMass transportSoluteThoracic aortic aneurysm

Identifiers

PMID36334323
PMCPMC9808669
OpenAlexW4307570006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.