Evidence map›Paper›PMID 36334230›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2022

Gastrointestinal manifestations in children with primary immune deficiencies: A case series.

Meena Sivasankaran, Venkateswari Ramesh, Srinivas Sankaranarayanan, Deenadayalan Munirathnam

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Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Meena SivasankaranDepartment of Pediatric Hemato-Oncology, Blood and Marrow Transplantation, Kanchi Kamakoti CHILDs Trust Hospital, 12A Nageswara Road, Numgambakkam, Chennai, 600 034, India. meenasankaran04@gmail.com.ORCID 0000-0001-5759-125X
Venkateswari RameshDepartment of Pediatrics, Kanchi Kamakoti CHILDs Trust Hospital, Numgambakkam, Chennai, 600 034, India.
Srinivas SankaranarayananDepartment of Pediatric Gastroenterology, Kanchi Kamakoti CHILDS Trust Hospital, Numgambakkam, Chennai, 600 034, India.
Deenadayalan MunirathnamDepartment of Pediatric Hemato-Oncology, Blood and Marrow Transplantation, Kanchi Kamakoti CHILDs Trust Hospital, 12A Nageswara Road, Numgambakkam, Chennai, 600 034, India.
Kanchi Kamakoti CHILDS Trust Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal (GI) manifestations are the second most common complications of primary immune deficiencies (PIDs) after pulmonary disease, affecting up to one-half of children with PIDs. Non-infectious GI manifestations such as allergic, autoimmune, and inflammatory disorders can be the predominant manifestations of PIDs. We present a series of five children who presented predominantly with these GI manifestations of PID, not attributable to infections. Very early age of onset (infancy), parental consanguinity, and failure to respond to hypoallergenic formula led to strong suspicion for underlying PIDs. Next-generation sequencing led to the underlying genetic diagnosis. Early diagnosis and hematopoietic stem cell transplantation could be life-saving in these children.

Indexed as

HypersensitivityImmunologic Deficiency SyndromesPrimary Immunodeficiency DiseasesChildGastrointestinal TractHumansResearchAllergyAutoimmunityConsanguinityDiarrheaGastrointestinal tractGenetic analysisHematopoietic stem cell transplantationImmune dysregulationInflammatory bowel diseaseRecurrent infections

Identifiers

PMID36334230
OpenAlexW4308253599

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.