Evidence map›Paper›PMID 36334147›Full record

ArticleCellular and molecular life sciences : CMLS2022

Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization.

Javier García-Ceca, Sara Montero-Herradón, Ana González, Rosa Plaza, Agustín G Zapata

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Javier García-Ceca *Department of Cell Biology, Faculty of Biology, Complutense University of Madrid, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0002-0940-455X
Sara Montero-Herradón *Department of Cell Biology, Faculty of Biology, Complutense University of Madrid, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0003-2004-8987
Ana GonzálezDepartment of Cell Biology, Faculty of Biology, Complutense University of Madrid, 28040, Madrid, Spain.
Rosa PlazaDepartment of Cell Biology, Faculty of Biology, Complutense University of Madrid, 28040, Madrid, Spain.
Agustín G ZapataDepartment of Cell Biology, Faculty of Biology, Complutense University of Madrid, 28040, Madrid, Spain. zapata@ucm.es.ORCID http://orcid.org/0000-0003-0576-2672
Universidad Complutense de Madrid · ES

Funding

Comunidad de Madrid S2017/BMD-3692Instituto de Salud Carlos III RD16/0011/0002Instituto de Salud Carlos III RD21/0017/0010Ministerio de Ciencia, Innovación y Universidades RTI2018-093938-B-I00
6 · The paper itself

Abstract

Eph receptors and their ligands, Ephrins, are involved in the thymocyte-thymic epithelial cell (TEC) interactions, key for the functional maturation of both thymocytes and thymic epithelium. Several years ago, we reported that the lack of EphA4, a Eph of the subfamily A, coursed with reduced proportions of double positive (DP) thymocytes apparently due to an altered thymic epithelial stroma [Munoz et al. in J Immunol 177:804-813, 2006]. In the present study, we reevaluate the lymphoid, epithelial, and extracellular matrix (ECM) phenotype of EphA4

Indexed as

ThymocytesThymus GlandAnimalsCell DifferentiationEpithelial CellsExtracellular MatrixLymphocyte ActivationMiceReceptors, Eph FamilyReceptors, Eph FamilyCell migrationEph tyrosine kinase receptorsThymic microenvironmentsThymus

Identifiers

PMID36334147
PMCPMC9637064
OpenAlexW4308313663

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.