Evidence map›Paper›PMID 36334013›Full record

Trial reportJournal of clinical pharmacy and therapeutics2022

Remimazolam versus propofol for deep sedation/anaesthesia in upper gastrointestinal endoscopy in elderly patients: A multicenter, randomized controlled trial.

Kejian Lu, Shanshan Wei, Wenwen Ling, Yanxia Wei, Xuelian Ran, Huageng Huang, Meixu Wang, Ning Wei, Yanying Liao, Zailing Qin and 7 more

Open access · hybridAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical pharmacy and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 9 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 9 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  9. RemimazolamPeerJ · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Kejian LuDepartment of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0001-6226-2602
Shanshan WeiDepartment of Anesthesiology, Hechi Third People's Hospital, Hechi, Guangxi, China.
Wenwen LingDepartment of Anesthesiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, Guangxi, China.
Yanxia WeiDepartment of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Xuelian RanDepartment of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Huageng HuangDepartment of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Meixu WangDepartment of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Ning WeiDepartment of Anesthesiology, Hechi Third People's Hospital, Hechi, Guangxi, China.
Yanying LiaoDepartment of Anesthesiology, Hechi Third People's Hospital, Hechi, Guangxi, China.
Zailing QinDepartment of Anesthesiology, Hechi Third People's Hospital, Hechi, Guangxi, China.
Meitao PanDepartment of Anesthesiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, Guangxi, China.
Qimei WeiDepartment of Anesthesiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, Guangxi, China.
Liuhui FuDepartment of Anesthesiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, Guangxi, China.
Boquan XiongDepartment of Anesthesiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, Guangxi, China.
Chendong MaDepartment of Anesthesiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, Guangxi, China.
Jun JiangDepartment of Anesthesiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, Guangxi, China.
Yanjuan HuangDepartment of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0003-0744-9727
Liuzhou General Hospital · CNGuangxi Medical University · CNRiverside Hospital of Guangxi Zhuang Autonomous Region · CN

Funding

Guangxi Health Commission Self-funded Scientific Research Projects foundation Z20210001Guangxi Health Commission Self-funded Scientific Research Projects foundation Z-A20221153
6 · The paper itself

Abstract

BACKGROUND AND

objectivePropofol is the most commonly used sedative in gastrointestinal endoscopic procedures, but is associated with cardiorespiratory suppression, particularly in elderly patients. Remimazolam is a new short-acting GABA(A) receptor agonist with minimal impact on cardiorespiratory suppression, and may be a viable alternative in elderly patients undergoing endoscopic procedures.

methodsThis multicenter, randomized controlled trial was conducted between September 2020 and September 2021. Elderly patients (65-85 years of age) scheduled to undergo upper gastrointestinal endoscopy were randomized in 1:1 ratio to receive remimazolam tosilate (300 mg/h) or propofol (3 g/h) in addition to 50-μg fentanyl, until the Modified Observer's Assessment of Alertness/Sedation Scale (MOAA/S) reached ≤1. MOAA/S was maintained at 0 or 1 throughout the procedure using 2.5 mg remimazolam or 0.5 mg/kg propofol boluses in the two groups, respectively. The primary outcome was the rate of hypotension (defined as systolic blood pressure at ≤90 mmHg or > 30% decline vs. the baseline). Bradycardia was defined as heart rate ≤50 per minute; respiratory depression was defined as respiratory rate <8 per minute and/or SpO

resultsA total of 400 patients (161 men and 239 women; 70.4 ± 4.6 years of age) were enrolled (200 patients per group). Average body mass index was 22.2 ± 2.4 kg/m

conclusionRemimazolam was associated with a lower rate of hypotension in elderly patients undergoing upper gastrointestinal endoscopy under deep sedation/anaesthesia than propofol.

Indexed as

AnesthesiaDeep SedationHypotensionPropofolRespiratory InsufficiencyAgedBenzodiazepinesBradycardiaEndoscopy, GastrointestinalFemaleHumansHypnotics and SedativesMaleBenzodiazepinesHypnotics and SedativesPropofolremimazolamelderly patientspropofolremimazolamsedationupper gastrointestinal endoscopy

Identifiers

PMID36334013
PMCPMC10100088
OpenAlexW4308257797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.