ArticleBMC complementary medicine and therapies2022
Optimisation of Calophyllum inophyllum seed oil nanoemulsion as a potential wound healing agent.
Article in BMC complementary medicine and therapies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Formulation Attributes and Preclinical Wound Healing Outcomes of Natural Product Based Nanoemulsions: A Systematic Review.International journal of nanomedicine · 2026Pooled it
- Synergistic phyto-formulated microemulsion for improved collagen deposition and healing of infected wounds.Discover nano · 2026Article
- Biofabrication ofLife (Basel, Switzerland) · 2025Article
- Formulation and characterization of Caesalpinia decapetala seed oil nanoemulsion: physicochemical properties, stability, and antibacterial activity.Scientific reports · 2025Article
- An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based onMolecules (Basel, Switzerland) · 2023Article
- Formulation and Biomedical Activity of Oil-in-Water Nanoemulsion CombiningClinical, cosmetic and investigational dermatology · 2023Article
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6 authors at 2 institutions in 1 country.
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Abstract
backgroundEfficient delivery systems of Calophyllum inophyllum seed oil (CSO) in the form of nanoemulsion were optimised to enhance its stability and ensure its therapeutic efficiency as a potential agent for various biomedical applications.
methodResponse Surface Methodology (RSM) was used to determine the effects of independent variables (oil, surfactant, water percentage and homogenisation time) on physicochemical characteristics, including droplet size, polydispersity index and turbidity.
resultsThe optimised CSO nanoemulsion (CSONE) has a 46.68 nm particle size, 0.15 Polydispersity index value and 1.16 turbidity. After 4 weeks of storage at 5 ± 1 °C and 25 ± 1 °C, the CSONE was physically stable. The optimised CSO nanoemulsion showed enhancement in cell viability and wound healing in baby hamster kidney a clone BHK-21 (BSR) cells as compared to the CSO. The wound healing property of CSONE was higher than CSO.
conclusionThus, our in vitro wound healing results demonstrated that CSO in the nanoemulsion form can promote wound healing by enhancing the proliferation and migration of epidermal cells. The coarse emulsion of Calophyllum inophyllum seed oil nano emulsion was prepared using high shear homogeniser techniques. The optimised CSONE with the droplet size of 46.68 nm was prepared from a mixture of CSO, Tween 80, and high pure water (HPW), then used for the biological investigation. The in vitro cell monolayer scratch assay revealed that CSONE in the lowest concentration of CSO resulted in 100% wound closure after 48 hrs. The optimised CSO nanoemulsion was found to be a promising and effective approach in the treatment of wounds by boosting the proliferation and migration of epidermal cells.
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