ArticleJournal of neuroinflammation2022
Single cell profiling of CD45
Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- The Pleiotropic Therapeutic Perspectives of GLP-1 and GIP Receptor Agonists in Spinal Cord Injury: A Narrative Review.Molecular neurobiology · 2026Review
- Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair.Cell reports · 2026Article
- Enhanced MIF/CD74 axis activity shapes B cell functioning following traumatic spinal cord injury.Journal of neuroinflammation · 2026Article
- Identification and Experimental Validation of Biomarkers Associated with PI3K/AKT Signaling Pathway in Spinal Cord Injury.Molecular neurobiology · 2026Article
- Pharmacological Inhibition of EZH2 by GSK-343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury.Journal of neuroscience research · 2026Article
- Longitudinal B Cell Receptor Repertoire Profiling of Heavy- and Light-Chain Features in Injured Rat Spinal Cord Tissue After Traumatic Spinal Cord Injury.ImmunoTargets and therapy · 2026Article
- Neutrophil extracellular traps released by CD177Cell communication and signaling : CCS · 2025Article
- Interplay of axon regeneration genes and immune infiltration in spinal cord injury.Journal of translational medicine · 2025Article
- Quercetin targets the Ccl4-Ccr5 axis to relieve neuropathic pain after spinal cord injury.APL bioengineering · 2025Article
- Role of dendritic cells in spinal cord injury.CNS neuroscience & therapeutics · 2024Review
- The molecular landscape of neurological disorders: insights from single-cell RNA sequencing in neurology and neurosurgery.European journal of medical research · 2023Review
- Ambient RNAs removal of cortex-specific snRNA-seq reveals ApoeJournal of neuroinflammation · 2023Article
- Rewiring the seizing brain: stem cell grafts as neuromodulatory architects in epilepsy therapy.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundImmune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies. We leveraged single-cell observations to describe key populations of immune cells present in the spinal cord and changes in their transcriptional profiles from uninjured to subacute and chronic stages of SCI.
methodsDeep-read single-cell sequencing was performed on CD45
resultsIn uninjured and 7 dpi spinal cord, most CD45
conclusionsImmune cell responses to SCI have region-specific aspects and evolve with time. Developmentally diverse populations of B cells accumulate in the spinal cord following injury. Microglia at subacute stages express B cell recruitment factors, while chronically, they express factors predicted to reduce B cell inflammatory state. In the injured spinal cord, B cells create ectopic lymphoid structures, and express secreted factors potentially acting on microglia. Our study predicts previously unidentified crosstalk between microglia and B cells post-injury at acute and chronic stages, revealing new potential targets of inflammatory responses for SCI repair warranting future functional analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.