Evidence map›Paper›PMID 36333744›Full record

ArticleBMC veterinary research2022

Effect of up to 30-days of storage at different temperatures on detection of feline kidney injury molecule-1 in urine.

Aleksandra Milaszewska, Alice Defarges, Michelle Oblak, Brigitte Brisson, Gabrielle Monteith, Dorothee Bienzle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aleksandra MilaszewskaDepartment of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Alice DefargesDepartment of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Michelle OblakDepartment of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Brigitte BrissonDepartment of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Gabrielle MonteithDepartment of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Dorothee BienzleDepartment of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada. dbienzle@uoguelph.ca.
University of Guelph · CA

Funding

Pet Trust Foundation 054321
6 · The paper itself

Abstract

backgroundIn humans, kidney injury molecule-1 (KIM-1) is a biomarker of acute kidney injury that can be quantified in urine. Preliminary investigation in cats with experimentally induced acute kidney injury showed that KIM-1 urine concentration correlated with kidney injury histopathology scores. A lateral flow assay (LFA) has recently become available for patient-side feline KIM-1 measurement. In vitro parameters of the assay have not yet been determined. The objectives of this study were to determine detection of KIM-1 in urine stored at different temperatures over time, to establish the linear range of the LFA, and to assess the intra-assay repeatability of measurements. 

resultsTen urine samples with a range of KIM-1 concentrations were stored at room temperature (22

conclusionsThe LFA for feline KIM-1 yields consistent results from stored urine samples. These characteristics will allow for KIM-1 to be measured retrospectively if immediate testing is not feasible. Within assay precision was high, and linearity over 9 logs of dilution suggests suitability for a range of subclinical and clinical kidney injuries.

Indexed as

Acute Kidney InjuryCat DiseasesAnimalsBiomarkersCatsHumansKidneyRetrospective StudiesTemperatureBiomarkersAcute kidney injuryBiomarkerChronic kidney diseaseKIM-1LFARenal failureValidation

Identifiers

PMID36333744
PMCPMC9635161
OpenAlexW4308177990

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.