Evidence map›Paper›PMID 36333501›Full record

SynthesisNature genetics2022

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.

Kazuyoshi Ishigaki, Saori Sakaue, Chikashi Terao, Yang Luo, Kyuto Sonehara, Kensuke Yamaguchi, Tiffany Amariuta, Chun Lai Too, Vincent A Laufer, Ian C Scott and 81 more

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 13 pooled it
48.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

210 citing papers in PubMed, 13 syntheses or guidelines pooled it, 332 citations in OpenAlex.

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150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

91 authors at 20 institutions in 17 countries.

Kazuyoshi Ishigaki *Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2881-0657
Saori Sakaue *Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3618-9717
Chikashi Terao *Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-6452-4095
Yang LuoCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7385-6166
Kyuto SoneharaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Kensuke YamaguchiDepartment of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0001-8288-1240
Tiffany AmariutaCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0121-1726
Chun Lai TooImmunogenetics Unit, Allergy and Immunology Research Center, Institute for Medical Research, National Institutes of Health Complex, Ministry of Health, Kuala Lumpur, Malaysia.
Vincent A LauferDepartment of Clinical Immunology and Rheumatology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Ian C ScottHaywood Academic Rheumatology Centre, Haywood Hospital, Midlands Partnership NHS Foundation Trust, Burslem, UK.ORCID http://orcid.org/0000-0002-1268-9808
Sebastien ViatteCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0001-6471-3358
Meiko TakahashiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID http://orcid.org/0000-0002-8344-5472
Koichiro OhmuraDepartment of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Akira MurasawaDepartment of Rheumatology, Niigata Rheumatic Center, Niigata, Japan.
Motomu HashimotoDepartment of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hiromu ItoDepartment of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID http://orcid.org/0000-0002-1827-382X
Mohammed HammoudehRheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
Samar Al EmadiRheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
Basel K MasriDepartment of Internal Medicine, Jordan Hospital, Amman, Jordan.
Hussein HalabiSection of Rheumatology, Department of Internal Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.ORCID http://orcid.org/0000-0002-5174-8292
Humeira BadshaDr. Humeira Badsha Medical Center, Emirates Hospital, Dubai, United Arab Emirates.
Imad W UthmanDepartment of Rheumatology, American University of Beirut, Beirut, Lebanon.
Xin WuDepartment of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.
Li LinDepartment of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.
Ting LiDepartment of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.
Darren PlantCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0003-1395-9344
Anne BartonCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0003-3316-2527
Gisela OrozcoCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0002-3479-0448
Suzanne M M VerstappenNIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
John BowesCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0003-4659-031X
Alexander J MacGregorNorwich Medical School, University of East Anglia, Norwich, UK.
Suguru HondaInstitute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
Masaru KoidoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-0348-0666
Kohei TomizukaLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoichiro KamataniLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Hiroaki TanakaThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan.
Eiichi TanakaInstitute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2850-326X
Akari SuzukiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yuichi MaedaIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.
Kenichi YamamotoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID http://orcid.org/0000-0001-9594-7050
Satoru MiyawakiDepartment of Neurosurgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.
Gang XieLunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada.
Jinyi ZhangLunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada.
Christopher I AmosBaylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8540-7023
Edward KeystoneThe University of Toronto, Toronto, Ontario, Canada.
Gertjan WolbinkDepartment of Rheumatology, Amsterdam Rheumatology and Immunology Center (ARC), Reade, Amsterdam, the Netherlands.
Irene van der Horst-BruinsmaDepartment of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location Vrije Universiteit, Amsterdam, the Netherlands.
Jing CuiDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Katherine P LiaoDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4797-3200
Robert J CarrollDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Hye-Soon LeeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
So-Young BangDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Katherine A SiminovitchLunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada.
Niek de VriesDepartment of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location AMC/University of Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-6257-8604
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1688-6697
Solbritt Rantapää-DahlqvistDepartment of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0001-8259-3863
Elizabeth W KarlsonDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sang-Cheol BaeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.ORCID http://orcid.org/0000-0003-4658-1093
Robert P KimberlyCenter for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jeffrey C EdbergCenter for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Xavier MarietteDepartment of Rheumatology, Université Paris-Saclay, Assistance Pubique - Hôpitaux de Paris, Hôpital Bicêtre, INSERM UMR1184, Le Kremlin Bicêtre, France.ORCID http://orcid.org/0000-0002-4244-5417
Tom HuizingaLeiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-7033-7520
Philippe DieudéUniversity of Paris Cité, Inserm, PHERE, F-75018, Paris, France.ORCID http://orcid.org/0000-0002-4814-0307
Matthias SchneiderDepartment of Rheumatology & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany.
Martin KerickInstitute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.ORCID http://orcid.org/0000-0002-6298-4514
Joshua C DennyDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
BioBank Japan Project
Koichi MatsudaLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Tsuneyo MimoriDepartment of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Keishi FujioDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshiya TanakaThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan.ORCID http://orcid.org/0000-0002-0807-7139
Atsushi KumanogohIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.ORCID http://orcid.org/0000-0003-4749-7117
Matthew TraylorDepartment of Medical & Molecular Genetics, King's College London, London, UK.
Cathryn M LewisDepartment of Medical & Molecular Genetics, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8249-8476
Stephen EyreCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0002-1251-6974
Huji XuDepartment of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.
Richa SaxenaProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2233-1065
Thurayya ArayssiDepartment of Internal Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.
Yuta KochiDepartment of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-8012-5078
Katsunori IkariInstitute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9066-2005
Masayoshi HarigaiInstitute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6418-2603
Peter K GregersenRobert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Kazuhiko YamamotoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
S Louis BridgesDepartment of Medicine, Hospital for Special Surgery, New York, NY, USA.
Leonid PadyukovDepartment of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2950-5670
Javier MartinInstitute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.ORCID http://orcid.org/0000-0002-2202-0622
Lars KlareskogDepartment of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9601-6186
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-0311-8472
Soumya RaychaudhuriCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.ORCID http://orcid.org/0000-0002-1901-8265
Kyoto University · JPBroad Institute · USManchester Academic Health Science Centre · GBRIKEN Center for Integrative Medical Sciences · JPBrigham and Women's Hospital · USSecond Military Medical University · CNHanyang University Seoul Hospital · KRKarolinska University Hospital · SETokyo Women's Medical University Hospital · JPUniversity of Alabama at Birmingham · USUniversity of Occupational and Environmental Health Japan · JPUniversity of Toronto · CAAmsterdam University Medical Centers · NLHamad Medical Corporation · QAHospital for Special Surgery · USInserm · FRKing's College London · GBNorthwell Health · USThe University of Osaka · JPThe University of Tokyo · JP

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Novel Biomarkers and Prediction Models for Rheumatoid ArthritisR01AR049880 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COSTENBADER, KAREN H, KARLSON, ELIZABETH W · 2003 to 2018
$8.7M
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4M
Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC)UC2AR081023 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2022 to 2026
$4.8M
RA-SLE Molecular Deconstruction Leadership CenterUH2AR067677 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2014 to 2020
$4.3M
Predicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2M
Training Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6M
Department of Health NIHR300826NCATS NIH HHS UL1 TR003096NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA067262NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107NHGRI NIH HHS T32 HG002295NHGRI NIH HHS U01 HG009379NHGRI NIH HHS U01 HG012009NIAMS NIH HHS R01 AR049880NIAMS NIH HHS R01 AR063759NIAMS NIH HHS T32 AR069516NIAMS NIH HHS UC2 AR081023NIAMS NIH HHS UH2 AR067677Versus Arthritis 19739Versus Arthritis 21229Wellcome Trust 207491/Z/17/Z
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P < 5 × 10

Indexed as

Arthritis, RheumatoidGenome-Wide Association StudyAdaptor Proteins, Signal TransducingAsian PeopleGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingTNIP2 protein, human

Identifiers

PMID36333501
PMCPMC10165422
OpenAlexW4308211464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.