Evidence map›Paper›PMID 36333482›Full record

ReviewNeuroscience bulletin2022

Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery.

Zhengrun Gao, Zhen Pang, Yiming Chen, Gaowei Lei, Shuai Zhu, Guotao Li, Yundong Shen, Wendong Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Ageing, Neurodegeneration and the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhengrun Gao *Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhen Pang *Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yiming ChenDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Gaowei LeiDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Shuai ZhuDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Guotao LiInstitute of Automation, State Key Laboratory of Management and Control for Complex Systems, Chinese Academy of Sciences, Beijing, 100190, China.
Yundong ShenDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wendong XuDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. wendongxu@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord injury, are leading causes of long-term disability. It is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated limb. Previous studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote recovery. However, the ability to increase plasticity in the injured brain is restricted and difficult to improve. Therefore, over several decades, researchers have been prompted to enhance the compensation by the unaffected hemisphere. Animal experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor function. In addition, several clinical treatments have been designed to restore ipsilateral motor control, including brain stimulation, nerve transfer surgery, and brain-computer interface systems. Here, we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries.

Indexed as

Spinal Cord InjuriesStrokeAnimalsBrainMotor NeuronsRecovery of FunctionAxon regrowthBrain–computer interface systemIpsilateral motor controlNeuroplasticitySpinal cord injuryStrokeTraumatic brain injury

Identifiers

PMID36333482
PMCPMC9723055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.