Evidence map›Paper›PMID 36333415›Full record

ArticleScientific reports2022

Cochlear motion across the reticular lamina implies that it is not a stiff plate.

Nam Hyun Cho, Sunil Puria

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 35 citations in OpenAlex.

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  14. Corti Fluid Is a Medium for Outer Hair Cell Force Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Review
  16. Frontiers in audiology and otology · 2025
    Article
  17. Tuning and Timing of Organ of Corti Vibrations at the Apex of the Intact Chinchilla Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nam Hyun ChoDepartment of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, 02114, USA.
Sunil PuriaDepartment of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, 02114, USA. Sunil_Puria@meei.harvard.edu.
Eaton (United States) · USMassachusetts Eye and Ear Infirmary · US

Funding

Three-dimensional and Multiscale Organ of Corti BiomechanicsR01DC007910 · NIDCD · STANFORD UNIVERSITY · PI Sunil Puria · 2007 to 2026
$9.4M
NIDCD NIH HHS R01 DC007910
6 · The paper itself

Abstract

Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina (RL) through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow mammals with sensitive hearing. Anatomical differences across OHC rows suggest differences in their motion. Using optical coherence tomography, we measured in vivo and postmortem displacements through the gerbil round-window membrane from approximately the 40-47 kHz best-frequency (BF) regions. Our high spatial resolution allowed measurements across the RL surface at the tops of the three rows of individual OHCs and their bottoms, and across the BM. RL motion varied radially; the third-row gain was more than 3 times greater than that of the first row near BF, whereas the OHC-bottom motions remained similar. This implies that the RL mosaic, comprised of OHC and phalangeal-process tops joined together by adhesion molecules, is much more flexible than the Deiters' cells connected to the OHCs at their bottom surfaces. Postmortem, the measured points moved together approximately in phase. These imply that in vivo, the RL does not move as a stiff plate hinging around the pillar-cell heads near the first row as has been assumed, but that its mosaic-like structure may instead bend and/or stretch.

Indexed as

CochleaOrgan of CortiAnimalsBasilar MembraneGerbillinaeHair Cells, Auditory, OuterMotion

Identifiers

PMID36333415
PMCPMC9636238
OpenAlexW4308296611

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.