Evidence map›Paper›PMID 36333410›Full record

ArticleNPJ precision oncology2022

Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling.

Shinji Kohsaka, Yuichiro Tada, Mizuo Ando, Masato Nakaguro, Yukina Shirai, Toshihide Ueno, Shinya Kojima, Hideaki Hirai, Natsuki Saigusa, Satoshi Kano and 27 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Fibroblast growth factor receptor signaling in head and neck tumors: molecular pathogenesis and potential therapeutic targets.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 19 institutions in 2 countries.

Shinji KohsakaDivision of Cellular Signaling, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. skohsaka@ncc.go.jp.ORCID http://orcid.org/0000-0001-8651-6136
Yuichiro TadaDepartment of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan. ytada@iuhw.ac.jp.ORCID http://orcid.org/0000-0002-0159-8660
Mizuo AndoDepartment of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.ORCID http://orcid.org/0000-0002-0754-2545
Masato NakaguroDepartment of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Yukina ShiraiDivision of Cellular Signaling, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Toshihide UenoDivision of Cellular Signaling, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.ORCID http://orcid.org/0000-0002-7408-7298
Shinya KojimaDivision of Cellular Signaling, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Hideaki HiraiDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Natsuki SaigusaDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Satoshi KanoDepartment of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kiyoaki TsukaharaDepartment of Otolaryngology Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Takafumi TogashiDepartment of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
Hiroyuki OzawaDepartment of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Takahito KondoDepartment of Otolaryngology Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
Kenji OkamiDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Hideaki TakahashiDepartment of Otolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Daisuke KawakitaDepartment of Otolaryngology Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Chihiro FushimiDepartment of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
Takayoshi SuzukiDepartment of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Akira ShimizuDepartment of Otolaryngology Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Isaku OkamotoDepartment of Otolaryngology Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Takuro OkadaDepartment of Otolaryngology Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Yuichiro SatoDepartment of Otolaryngology and Head and Neck Surgery, School of Life Dentistry at Niigata, The Nippon Dental University, Tokyo, Japan.
Yorihisa ImanishiDepartment of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0047-7987
Yoshihiro WatanabeDepartment of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Akihiro SakaiDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Koji EbisumotoDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Yukiko SatoDivision of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4277-0161
Makoto UranoDepartment of Diagnostic Pathology Bantane Hospital Fujita Health University, School of Medicine, Nagoya, Japan.
Yoshitaka HonmaDepartment of Head & Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Keisuke YamazakiDepartment of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Yushi UekiDepartment of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Toyoyuki HanazawaDepartment of Otorhinolaryngology/Head & Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Yuki SaitoDepartment of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Tomotaka ShimuraDepartment of Otorhinolaryngology, Showa University Fujigaoka Hospital, Yokohama, Japan.
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2075-9738
Hiroyuki ManoDivision of Cellular Signaling, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. hmano@ncc.go.jp.ORCID http://orcid.org/0000-0003-4645-0181
Tokyo Medical University · JPKeio University · JPTokai University · JPHokkaido University · JPMita Hospital · JPNational Cancer Research Institute · GBNiigata University · JPNippon Dental University · JPChiba University · JPFujita Health University · JPNagoya City University · JPNagoya University Hospital · JPNational Cancer Center Hospital East · JPNiigata Cancer Center Hospital · JPOkayama University · JPShowa University Fujigaoka Hospital · JPThe University of Tokyo · JPTokyo Medical University Hachioji Medical Center · JPYokohama City University · JP

Funding

Japan Agency for Medical Research and Development (AMED) JP20ck0106536Japan Agency for Medical Research and Development (AMED) JP20cm0106502MEXT | Japan Society for the Promotion of Science (JSPS) 18K09386MEXT | Japan Society for the Promotion of Science (JSPS) 20K07417
6 · The paper itself

Abstract

Molecular targets and predictive biomarkers for prognosis in salivary duct carcinoma (SDC) have not been fully identified. We conducted comprehensive molecular profiling to discover novel biomarkers for SDC. A total of 67 SDC samples were examined with DNA sequencing of 464 genes and transcriptome analysis in combination with the clinicopathological characteristics of the individuals. Prognostic biomarkers associated with response to combined androgen blockade (CAB) treatment were explored using mRNA expression data from 27 cases. Oncogenic mutations in receptor tyrosine kinase (RTK) genes or genes in the MAPK pathway were identified in 55 cases (82.1%). Alterations in the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway were identified in 38 cases (56.7%). Interestingly, patient prognosis could be predicted using mRNA expression profiles, but not genetic mutation profiles. The risk score generated from the expression data of a four-gene set that includes the ADAMTS1, DSC1, RNF39, and IGLL5 genes was a significant prognostic marker for overall survival in the cohort (HR = 5.99, 95% confidence interval (CI) = 2.73-13.1, p = 7.8 × 10

Identifiers

PMID36333410
PMCPMC9636405
OpenAlexW4308298186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.