Evidence map›Paper›PMID 36333408›Full record

ArticleScientific reports2022

Expression of DNA repair genes and its relevance for DNA repair in peripheral immune cells of patients with posttraumatic stress disorder.

Alexander Behnke, Matthias Mack, Judy Fieres, Markus Christmann, Alexander Bürkle, María Moreno-Villanueva, Iris-Tatjana Kolassa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexander Behnke *Clinical and Biological Psychology, Institute of Psychology and Education, Ulm University, Albert-Einstein-Allee 47, 89081, Ulm, Germany.
Matthias Mack *Clinical and Biological Psychology, Institute of Psychology and Education, Ulm University, Albert-Einstein-Allee 47, 89081, Ulm, Germany. Matthias.mack@uni-ulm.de.
Judy FieresMolecular Toxicology, Department of Biology, University of Konstanz, 78457, Constance, Germany.
Markus ChristmannApplied Toxicology, Institute of Toxicology, University of Mainz, 55131, Mainz, Germany.
Alexander BürkleMolecular Toxicology, Department of Biology, University of Konstanz, 78457, Constance, Germany.
María Moreno-VillanuevaMolecular Toxicology, Department of Biology, University of Konstanz, 78457, Constance, Germany.
Iris-Tatjana KolassaClinical and Biological Psychology, Institute of Psychology and Education, Ulm University, Albert-Einstein-Allee 47, 89081, Ulm, Germany.
University of Konstanz · DEUniversität Ulm · DEJohannes Gutenberg University Mainz · DE

Funding

Deutsche Forschungsgemeinschaft Ko 3895/1
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) involves elevated levels of cellular oxidative stress which jeopardizes the integrity of essential cell compartments. Previously, we demonstrated higher levels of DNA lesions in peripheral blood mononuclear cells (PBMCs) in PTSD. Retaining vital levels of DNA integrity requires cells to mobilize compensatory efforts in elevating their DNA-repair capacity. Accordingly, we hypothesized to find increased expression rates of the DNA-repair genes X-ray repair cross complementing 1 (XRCC1), poly (ADP-ribose) polymerase 1 (PARP1), and polymerase β (Polβ) in PBMCs of PTSD patients as compared to controls, leading to functionally relevant changes in DNA-repair kinetics. In a cohort of 14 refugees with PTSD and 15 without PTSD, we found significantly higher XRCC1 expression in PTSD patients than controls (U = 161.0, p = 0.009, Cohen's r = 0.49), and positive correlations between the severity of PTSD symptoms and the expression of XRCC1 (r

Indexed as

Stress Disorders, Post-TraumaticDNADNA-Binding ProteinsDNA DamageDNA RepairHumansLeukocytes, MononuclearPoly (ADP-Ribose) Polymerase-1X-ray Repair Cross Complementing Protein 1DNADNA-Binding ProteinsPoly (ADP-Ribose) Polymerase-1X-ray Repair Cross Complementing Protein 1XRCC1 protein, human

Identifiers

PMID36333408
PMCPMC9636148
OpenAlexW4308342789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.