Evidence map›Paper›PMID 36333379›Full record

ArticleNature communications2022

Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes.

Timothy M Moore, Lijing Cheng, Dane M Wolf, Jennifer Ngo, Mayuko Segawa, Xiaopeng Zhu, Alexander R Strumwasser, Yang Cao, Bethan L Clifford, Alice Ma and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Article
  8. STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.Journal of cachexia, sarcopenia and muscle · 2025
    Article
  9. Article
  10. Molecular mechanisms of mitochondrial quality control.Translational neurodegeneration · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 4 countries.

Timothy M Moore *Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0003-4250-3370
Lijing Cheng *Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Dane M WolfDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Jennifer NgoDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Mayuko SegawaDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Xiaopeng ZhuDivision of Pediatric Endocrinology, Department of Pediatrics UCLA Children's Discovery and Innovation Institute, University of California, Los Angeles, CA, 90095, USA.
Alexander R StrumwasserDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Yang CaoDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Bethan L CliffordDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Alice MaDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Philip ScumpiaDivision of Dermatology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0002-2563-2042
Orian S ShirihaiDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-8466-3431
Thomas Q de Aguiar VallimDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210, Kuopio, Finland.
Aldons J LusisDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-9013-0228
Andrea L HevenerDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.
Zhenqi ZhouDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, 90095, USA. zhenqizhou@mednet.ucla.edu.ORCID 0000-0001-6560-9704
University of California, Los Angeles · USUniversity of Eastern Finland · FI

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Sex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6M
UCLA Medical Genetics Training ProgramT32GM008243 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Julian Martinez-Agosto, STANLEY F. NELSON · 1987 to 2026
$6.8M
Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Role of dynamin-related protein 1 in the regulation of metabolism and skeletal muscle massR01DK125354 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, ZHENQI · 2021 to 2025
$2.5M
Mechanisms controlling skeletal muscle mitochondrial function and metabolic healthR01DK109724 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEVENER, ANDREA L · 2016 to 2020
$2.4M
Mitochondrial DNA Health and Metabolic HomeostasisF31DK108657 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MOORE, TIMOTHY MICHAEL · 2016 to 2018
$126k
NIDDK NIH HHS F31 DK108657NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK109724NIDDK NIH HHS R01 DK117850NIDDK NIH HHS R01 DK125354NIDDK NIH HHS U54 DK120342NIGMS NIH HHS T32 GM008243
6 · The paper itself

Abstract

Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue remain unclear. Here, we demonstrate that Park2 gene (encodes Parkin) deletion specifically from adipose tissue protects mice against high-fat diet and aging-induced obesity. Despite a mild reduction in mitophagy, mitochondrial DNA content and mitochondrial function are increased in Park2 deficient white adipocytes. Moreover, Park2 gene deletion elevates mitochondrial biogenesis by increasing Pgc1α protein stability through mitochondrial superoxide-activated NAD(P)H quinone dehydrogenase 1 (Nqo1). Both in vitro and in vivo studies show that Nqo1 overexpression elevates Pgc1α protein level and mitochondrial DNA content and enhances mitochondrial activity in mouse and human adipocytes. Taken together, our findings indicate that Parkin regulates mitochondrial homeostasis by balancing mitophagy and Pgc1α-mediated mitochondrial biogenesis in white adipocytes, suggesting a potential therapeutic target in adipocytes to combat obesity and obesity-associated disorders.

Indexed as

MitophagyOrganelle BiogenesisAdipocytes, WhiteAdiposityAnimalsDNA, MitochondrialHumansMiceObesityPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaUbiquitin-Protein LigasesDNA, MitochondrialPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaUbiquitin-Protein Ligases

Identifiers

PMID36333379
PMCPMC9636263
OpenAlexW4308296203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.