Evidence map›Paper›PMID 36333367›Full record

ArticleScientific reports2022

Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system.

Erika Horta, Conor Burke-Smith, Bryant W Megna, Kendall J Nichols, Byron P Vaughn, Rwoof Reshi, Eugenia Shmidt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Erika HortaDepartment of Neurology, University of Arkansas Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA.
Conor Burke-SmithUniversity of Iowa Carver College of Medicine, 375 Newton Rd, Iowa City, IA, 52242, USA.
Bryant W MegnaInflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of Minnesota, 516 Delaware St Se, Minneapolis, MN, 55455, USA. Megna003@umn.edu.
Kendall J NicholsDepartment of Neurology, University of Minnesota, 516 Delaware St SE, Minneapolis, MN, 55455, USA.
Byron P VaughnInflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of Minnesota, 516 Delaware St Se, Minneapolis, MN, 55455, USA.
Rwoof ReshiThe University of Oklahoma Health Sciences Center, 865 Research Pkwy, Oklahoma City, OK, 73104, USA.
Eugenia ShmidtInflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of Minnesota, 516 Delaware St Se, Minneapolis, MN, 55455, USA.
University of Minnesota · USUniversity of Arkansas for Medical Sciences · USUniversity of Iowa · USUniversity of Oklahoma Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In general, IBD increases arteriovenous thromboembolic events, though the association between UC and cerebrovascular complications remains inconclusive. Some studies suggest young women with UC have an increased risk of cerebrovascular accidents (CVA). The focus of this study was to characterize the rates, anatomic distribution, and risk factors for CVA in patients with UC. We developed a retrospective cohort of patients with UC at a single health care system from June 2010 to June 2015. Neuroimaging was used to document presence, location and type of stroke and traditional risk factors were considered. Prevalence of CVAs in patients with UC was compared to that of the general population of Minnesota (MN) and the United States (U.S.). A total of 2,183 UC patients were identified (1088 females [f-UC], 1095 males [m-UC]). The prevalence of CVA in UC patients (4.7%, 95% CI 3.9-5.6) was higher than in the U.S. (2.5-2.7%, p < 0.0001) and in Minnesota (1.8% CI 1.5-2.2, p < 0.0001) . The prevalence increased in both sexes with a peak prevalence of 24.7% (95% CI 17.1-34.4) in women with UC over the age of 80. Older age, cancer and atrial fibrillation were risk factors for CVA in univariate analysis for both sexes. In multifactorial analysis, both age and atrial fibrillation were risk factors for CVA in the m-UC cohort, but only age was associated with CVA in f-UC. The most common type of CVA was ischemic stroke (77.7%). The most common locations for CVAs in UC patients were frontal and occipital lobes (19% and 18%, respectively). UC patients have an increased risk for CVA, with women over 80 demonstrating the highest risk. Providers should be aware of these risks in making treatment decisions for UC.

Indexed as

Atrial FibrillationColitis, UlcerativeStrokeFemaleHumansMalePrevalenceRetrospective StudiesRisk FactorsUnited States

Identifiers

PMID36333367
PMCPMC9636207
OpenAlexW4308342872

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.