Evidence map›Paper›PMID 36333337›Full record

ArticleNPJ systems biology and applications2022

Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol.

Shugang Zhang, Weigang Lu, Fei Yang, Zhen Li, Shuang Wang, Mingjian Jiang, Xiaofeng Wang, Zhiqiang Wei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ systems biology and applications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Frontiers in physiology · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Shugang ZhangCollege of Computer Science and Technology, Ocean University of China, Qingdao, 266100, China.
Weigang LuDepartment of Educational Technology, Ocean University of China, Qingdao, 266100, China. luweigang@ouc.edu.cn.ORCID 0000-0002-1767-5309
Fei YangSchool of Mechanical, Electrical, and Information Engineering, Shandong University, Weihai, 264200, China.
Zhen LiCollege of Computer Science and Technology, Qingdao University, Qingdao, 266071, China.
Shuang WangCollege of Computer Science and Technology, China University of Petroleum (East China), Qingdao, 266580, China.
Mingjian JiangSchool of Information and Control Engineering, Qingdao University of Technology, Qingdao, 266033, China.
Xiaofeng WangMindRank AI ltd., Hangzhou, Zhejiang, 311113, China.
Zhiqiang WeiCollege of Computer Science and Technology, Ocean University of China, Qingdao, 266100, China.
Ocean University of China · CNChina University of Petroleum, East China · CNMinistry of Culture · BRQingdao University of Science and Technology · CNShandong University · CNUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short QT syndrome (SQTS) is a rare but dangerous genetic disease. In this research, we conducted a comprehensive in silico investigation into the arrhythmogenesis in KCNH2 T618I-associated SQTS using a multi-scale human ventricle model. A Markov chain model of I

Indexed as

QuinidineSotalolAction PotentialsAnti-Arrhythmia AgentsArrhythmias, CardiacERG1 Potassium ChannelHumansMutationAnti-Arrhythmia AgentsERG1 Potassium ChannelKCNH2 protein, humanQuinidineSotalol

Identifiers

PMID36333337
PMCPMC9636227
OpenAlexW4308450285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.