Evidence map›Paper›PMID 36333326›Full record

ArticleNature communications2022

Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats.

Bing-Yi Wang, Zhijie Charles Chen, Mohajeet Bhuckory, Tiffany Huang, Andrew Shin, Valentina Zuckerman, Elton Ho, Ethan Rosenfeld, Ludwig Galambos, Theodore Kamins and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 72 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025
    Review
  12. Article
  13. A flexible photoacoustic retinal prosthesis.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Bing-Yi Wang *Department of Physics, Stanford University, Stanford, CA, USA. bingyiw@stanford.edu.ORCID 0000-0001-8336-3285
Zhijie Charles Chen *Department of Electrical Engineering, Stanford University, Stanford, CA, USA. zcchen@stanford.edu.ORCID 0000-0003-2705-065X
Mohajeet BhuckoryHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Tiffany HuangDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Andrew ShinDepartment of Material Science, Stanford University, Stanford, CA, USA.
Valentina ZuckermanHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Elton HoHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4645-6156
Ethan RosenfeldHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8654-4900
Ludwig GalambosDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Theodore KaminsDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8319-1161
Keith MathiesonDepartment of Physics, Institute of Photonics, University of Strathclyde, Glasgow, Scotland, UK.ORCID 0000-0002-9517-8076
Daniel PalankerHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0480-3025
Stanford University · USStanford Medicine · USUniversity of Strathclyde · GB

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Photovoltaic Subretinal Prosthesis with High Pixel DensityR01EY027786 · NEI · STANFORD UNIVERSITY · PI PALANKER, DANIEL V · 2017 to 2021
$3.3M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY027786
6 · The paper itself

Abstract

Localized stimulation of the inner retinal neurons for high-acuity prosthetic vision requires small pixels and minimal crosstalk from the neighboring electrodes. Local return electrodes within each pixel limit the crosstalk, but they over-constrain the electric field, thus precluding the efficient stimulation with subretinal pixels smaller than 55 μm. Here we demonstrate a high-resolution prosthetic vision based on a novel design of a photovoltaic array, where field confinement is achieved dynamically, leveraging the adjustable conductivity of the diodes under forward bias to turn the designated pixels into transient returns. We validated the computational modeling of the field confinement in such an optically-controlled circuit by in-vitro and in-vivo measurements. Most importantly, using this strategy, we demonstrated that the grating acuity with 40 μm pixels matches the pixel pitch, while with 20 μm pixels, it reaches the 28 μm limit of the natural visual resolution in rats. This method enables customized field shaping based on individual retinal thickness and distance from the implant, paving the way to higher acuity of prosthetic vision in atrophic macular degeneration.

Indexed as

Visual ProsthesisAnimalsElectric StimulationElectronicsRatsRetinaVision, OcularVisual Acuity

Identifiers

PMID36333326
PMCPMC9636145
OpenAlexW4308342994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.