ArticleTranslational psychiatry2022
Maternal stress and vulnerability to depression: coping and maternal care strategies and its consequences on adolescent offspring.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- What Makes Parents of Young Children Stressed? A Systematic Review of Quantitative Studies.Clinical child and family psychology review · 2026Pooled it
- Effects of Serotonin Transporter Genotype and (Un)Predictable Maternal Separation on Affective, Cognitive, and Social Behaviors in Female Rats.Genes, brain, and behavior · 2026Article
- The impact of paternal PTSD-like stress on cognitive behavior and hippocampal BDNF expression in adolescent male and female rat offspring: modulatory effects of lithium.Behavioral and brain functions : BBF · 2026Article
- Maternal depression and offspring neurodevelopmental impairments in wild rodents induced by ecologically relevant prenatal stress.Molecular psychiatry · 2026Article
- Association Between Parental Smoking Status and Adolescent Mental Health: Population-Based Study.Asian/Pacific Island nursing journal · 2026Article
- Maternal dysbiosis produces long-lasting behavioral changes in offspring.Molecular psychiatry · 2025Article
- The impact of early life stress and schizophrenia on motor and cognitive functioning: an experimental study.Frontiers in integrative neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depressive mothers often find mother-child interaction to be challenging. Maternal stress may further impair mother-child attachment, which may increase the risk of negative developmental consequences. We used rats with different vulnerability to depressive-like behavior (Wistar and Kyoto) to investigate the impact of stress (maternal separation-MS) on maternal behavior and adolescent offspring cognition. MS in Kyoto dams increased pup-contact, resulting in higher oxytocin levels and lower anxiety-like behavior after weaning, while worsening their adolescent offspring cognitive behavior. Whereas MS in Wistar dams elicited higher quality of pup-directed behavior, increasing brain-derived neurotrophic factor (BDNF) in the offspring, which seems to have prevented a negative impact on cognition. Hypothalamic oxytocin seems to affect the salience of the social environment cues (negatively for Kyoto) leading to different coping strategies. Our findings highlight the importance of contextual and individual factors in the understanding of the oxytocin role in modulating maternal behavior and stress regulatory processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.