ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2023
Intensive Care Unit-Acquired Weakness in Patients With Acute Kidney Injury: A Contemporary Review.
Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05287204 (Critical Illness Myopathy and Trajectory of Recovery in Acute Kidney Injury), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Critical Illness Myopathy and Trajectory of Recovery in Acute Kidney Injury (AKI) Requiring Continuous Renal Replacement Therapy (CRRT): A Prospective Observational Trial
Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Nutritional support in acute kidney injury requiring continuous renal replacement therapy: from metabolic alterations to clinical recommendations.International urology and nephrology · 2026Review
- Metabolomic assessment reveals depletion of amino acids and energy metabolites in skeletal muscle after ischemic acute kidney injury in mice.Scientific reports · 2026Article
- Renal-tubular-mitochondrial sequentially targeted nanoagent breaks the vicious cycle of oxidative stress and mtDNA-driven inflammation in acute kidney injury therapy.Journal of nanobiotechnology · 2026Article
- Article
- Article
- A comprehensive evidence-based intervention programme significantly reduces intensive care unit-acquired weakness and improves functional recovery: a retrospective analysis.Journal of rehabilitation medicine · 2025Article
- Acute skeletal muscle wasting in patients with acute kidney injury requiring continuous kidney replacement therapy: A prospective multicenter study.Journal of critical care · 2025Observational
- Ultrasound-based assessment of muscle mass is associated with early recovery after kidney transplant: a prospective single-center study.BMC anesthesiology · 2025Article
- The Impact of Early Mobilization on the Incidence of Intensive Care Unit-Acquired Weakness in Patients with Sepsis in the Critical Care-The Shinshu Multicenter Prospective Cohort Study (EROSCCS Study).Journal of clinical medicine · 2025Article
- The extent of Skeletal muscle wasting in prolonged critical illness and its association with survival: insights from a retrospective single-center study.BMC anesthesiology · 2025Article
- Establishing discordance rate of estimated glomerular filtration rate between serum creatinine-based calculations and cystatin-C-based calculations in critically ill patients.Pharmacotherapy · 2025Observational
- Early urea-to-creatinine ratio to predict rapid muscle loss in critically ill patients with sepsis: a single-center retrospective observational study.BMC anesthesiology · 2025Observational
- The role of a "volume sparing" strategy in kidney replacement therapy of AKI: a retrospective single-center study.Journal of nephrology · 2025Observational
- Association of Geriatric Nutritional Risk Index with short-term mortality in patients with severe acute kidney injury: a retrospective cohort study.Renal failure · 2024Observational
- Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure.Renal failure · 2024Article
- Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses.Journal of intensive care · 2024Review
- Risk prediction models for successful discontinuation in acute kidney injury undergoing continuous renal replacement therapy.iScience · 2024Article
- The knowledge, attitude and behavior of ICU nurses regarding ICU-acquired weakness: a cross-sectional survey.BMC nursing · 2024Article
- Observational
- Intensive care unit-acquired weakness: Recent insights.Journal of intensive medicine · 2024Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Acute kidney injury (AKI) and intensive care unit-acquired weakness (ICU-AW) are 2 frequent complications of critical illness that, until recently, have been considered unrelated processes. The adverse impact of AKI on ICU mortality is clear, but its relationship with muscle weakness-a major source of ICU morbidity-has not been fully elucidated. Furthermore, improving ICU survival rates have refocused the field of intensive care toward improving long-term functional outcomes of ICU survivors. We begin our review with the epidemiology of AKI in the ICU and of ICU-AW, highlighting emerging data suggesting that AKI and AKI treated with kidney replacement therapy (AKI-KRT) may independently contribute to the development of ICU-AW. We then delve into human and animal data exploring the pathophysiologic mechanisms linking AKI and acute KRT to muscle wasting, including altered amino acid and protein metabolism, inflammatory signaling, and deleterious removal of micronutrients by KRT. We next discuss the currently available interventions that may mitigate the risk of ICU-AW in patients with AKI and AKI-KRT. We conclude that additional studies are needed to better characterize the epidemiologic and pathophysiologic relationship between AKI, AKI-KRT, and ICU-AW and to prospectively test interventions to improve the long-term functional status and quality of life of AKI survivors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.