Evidence map›Paper›PMID 36332617›Full record

ArticleCurrent biology : CB2022

Manipulating the nature of embryonic mitotic waves.

Luke Hayden, Woonyung Hur, Massimo Vergassola, Stefano Di Talia

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Coexistence of trapped and flow-transported nuclei enables fast pigeon post communication across multinucleated cell.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  9. Two-fluid dynamics and micron-thin boundary layers shape cytoplasmic flows in earlyProceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Luke HaydenDepartment of Cell Biology, Research Drive, Duke University School of Medicine, Durham, NC 27710, USA.
Woonyung HurDepartment of Cell Biology, Research Drive, Duke University School of Medicine, Durham, NC 27710, USA.
Massimo VergassolaLaboratoire de Physique de l'École Normale Supérieure, CNRS, PSL Research University, Sorbonne Université, 24 Rue Lhomond, 75005 Paris, France; Department of Physics, University of California, San Diego, 9500 Gillman Drive, La Jolla, CA 92093, USA. Electronic address: massimo.vergassola@phys.ens.fr.
Stefano Di TaliaDepartment of Cell Biology, Research Drive, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: stefano.ditalia@duke.edu.
Duke University · USCentre National de la Recherche Scientifique · FR

Funding

Time-keeping mechanisms of embryonic cell cyclesR01GM122936 · NIGMS · DUKE UNIVERSITY · PI DI TALIA, STEFANO · 2017 to 2023
$2.0M
KITP Interdisciplinary Biology InitiativeR25GM067110 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SHRAIMAN, BORIS I · 2003 to 2018
$1.8M
Mechanisms and developmental functions of cytoplasmic flows in early embryogenesisR01GM136763 · NIGMS · DUKE UNIVERSITY · PI DI TALIA, STEFANO · 2021 to 2023
$1.1M
NIGMS NIH HHS R01 GM122936NIGMS NIH HHS R01 GM136763NIGMS NIH HHS R25 GM067110
6 · The paper itself

Abstract

Early embryogenesis is characterized by rapid and synchronous cleavage divisions, which are often controlled by wave-like patterns of Cdk1 activity. Two mechanisms have been proposed for mitotic waves: sweep and trigger waves.

Indexed as

CDC2 Protein KinaseDrosophila ProteinsAnimalsBlastodermCell CycleDrosophilaMitosisCDC2 Protein KinaseDrosophila ProteinsbistabilityCdk1cell cycleCullin-5Drosophilaembryogenesismitotic wavesPoloreaction-diffusion equationstemperature

Identifiers

PMID36332617
PMCPMC9691596
OpenAlexW4308104007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.