Evidence map›Paper›PMID 36332548›Full record

ArticleEuropean journal of medicinal chemistry2022

Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2.

Simone Di Micco, Rahila Rahimova, Marina Sala, Maria C Scala, Giovanni Vivenzio, Simona Musella, Graciela Andrei, Kim Remans, Léa Mammri, Robert Snoeck and 6 more

Open access · greenAbstract read
In one paragraph

Article in European journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 5 countries.

Simone Di MiccoEuropean Biomedical Research Institute of Salerno (EBRIS), Via Salvatore de Renzi 50, 84125, Salerno, Italy. Electronic address: s.dimicco@ebris.eu.
Rahila RahimovaEuropean Molecular Biology Laboratory, EMBL, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9, 38042, France.
Marina SalaDipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Maria C ScalaDipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Giovanni VivenzioDipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Simona MusellaEuropean Biomedical Research Institute of Salerno (EBRIS), Via Salvatore de Renzi 50, 84125, Salerno, Italy; Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Graciela AndreiDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Kim RemansEuropean Molecular Biology Laboratory, EMBL, Meyerhofstraße 1, 69117, Heidelberg, Germany.
Léa MammriEuropean Molecular Biology Laboratory, EMBL, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9, 38042, France.
Robert SnoeckDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Giuseppe BifulcoDipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Francesca Di MatteoDipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Vincenzo VestutoDipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Pietro CampigliaEuropean Biomedical Research Institute of Salerno (EBRIS), Via Salvatore de Renzi 50, 84125, Salerno, Italy; Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
José A MárquezEuropean Molecular Biology Laboratory, EMBL, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9, 38042, France; ALPX S.A.S. 71, Avenue des Martyrs, France.
Alessio FasanoEuropean Biomedical Research Institute of Salerno (EBRIS), Via Salvatore de Renzi 50, 84125, Salerno, Italy; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, MA, 02114, USA.
University of Salerno · ITEuropean Molecular Biology Laboratory · FRRega Institute for Medical Research · BEEuropean Biomedical Research Institute of Salerno · ITEuropean Molecular Biology Laboratory · DEHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although vaccines are greatly mitigating the worldwide pandemic diffusion of SARS-Cov-2, therapeutics should provide many distinct advantages as complementary approach to control the viral spreading. Here, we report the development of new tripeptide derivatives of AT1001 against SARS-CoV-2 M

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2AnimalsAntiviral AgentsChlorocebus aethiopsCoronavirus 3C ProteasesHaptoglobinsHumansMolecular Docking SimulationProtease InhibitorsProtein PrecursorsVero CellsViral Nonstructural ProteinsAntiviral AgentsCoronavirus 3C ProteasesHaptoglobinsProtease InhibitorsProtein PrecursorsViral Nonstructural ProteinszonulinAntiviralCovalent inhibitorsMolecular modelingSARS-CoV-2X-ray crystallography

Identifiers

PMID36332548
PMCPMC9579148
OpenAlexW4306851299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.