Evidence map›Paper›PMID 36332546›Full record

ArticleEuropean journal of medicinal chemistry2022

Easy access to α-ketoamides as SARS-CoV-2 and MERS M

Sveva Pelliccia, Carmen Cerchia, Francesca Esposito, Rolando Cannalire, Angela Corona, Elisa Costanzi, Maria Kuzikov, Philip Gribbon, Andrea Zaliani, Margherita Brindisi and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Sveva PellicciaDepartment of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy. Electronic address: sveva.pelliccia@unina.it.
Carmen CerchiaDepartment of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy.
Francesca EspositoDipartimento di Scienze della Vita e dell'Ambiente, Cittadella Universitaria di Monserrato, Cagliari, Monserrato, SS-554, Italy.
Rolando CannalireDepartment of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy.
Angela CoronaDipartimento di Scienze della Vita e dell'Ambiente, Cittadella Universitaria di Monserrato, Cagliari, Monserrato, SS-554, Italy.
Elisa CostanziProtein Facility, Elettra - Sincrotrone Trieste S.C.p.A., SS 14 - km 163, 5 in AREA Science Park, Trieste, Basovizza, 34149, Italy.
Maria KuzikovFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, Hamburg, 22525, Germany; Department of Life Sciences and Chemistry, Jacobs University Bremen, 28759, Bremen, Germany; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.
Philip GribbonFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, Hamburg, 22525, Germany; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.
Andrea ZalianiFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, Hamburg, 22525, Germany; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.
Margherita BrindisiDepartment of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy.
Paola StoriciProtein Facility, Elettra - Sincrotrone Trieste S.C.p.A., SS 14 - km 163, 5 in AREA Science Park, Trieste, Basovizza, 34149, Italy.
Enzo TramontanoDipartimento di Scienze della Vita e dell'Ambiente, Cittadella Universitaria di Monserrato, Cagliari, Monserrato, SS-554, Italy.
Vincenzo SummaDepartment of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy. Electronic address: vincenzo.summa@unina.it.
University of Naples Federico II · ITIstituto Nazionale di Fisica Nucleare, Sezione di Cagliari · ITMerck (Germany) · DEElettra-Sincrotrone Trieste S.C.p.A. · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 caused worldwide the current outbreak called COVID-19. Despite multiple countermeasures implemented, there is an urgent global need for new potent and efficient antiviral drugs against this pathogen. In this context, the main protease (M

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesHumansMolecular Docking SimulationProtease InhibitorsViral Nonstructural ProteinsAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesProtease InhibitorsViral Nonstructural ProteinsMain protease inhibitorsMulticomponent reactionsPADAM-OxidationSARS-CoV-2α-ketoamides

Identifiers

PMID36332546
PMCPMC9575579
OpenAlexW4306630516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.