ArticleBlood2023
Neutrophil-specific depletion of gasdermin D does not protect against murine sepsis.
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In one paragraph
Article in Blood, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
–field-weighted citation impact
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Who cites it
17 citing papers in PubMed.
- Gasdermin D-driven pyroptosis in sepsis: mechanisms, therapeutic strategies, and clinical translation.Frontiers in immunology · 2026Review
- Emestrin-Type Epidithiodiketopiperazines Inhibited Gasdermin D-Mediated Pyroptosis via Caspase-3/7 Activation.MedComm · 2026Article
- Hepatocyte-Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non-Canonical Secretion of Anti-Inflammatory Factors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response.Nature immunology · 2025Article
- Selenium-Binding Protein 1-Deficient Dendritic Cells Protect Mice from Sepsis by Increased Treg/Th17.Antioxidants (Basel, Switzerland) · 2025Article
- Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- The dual role of neutrophils in sepsis-associated liver injury.Frontiers in immunology · 2025Review
- GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver.Cell death and differentiation · 2024Article
- Poly(ADP-Ribose) Polymerase-1 Regulates Pyroptosis Independent Function of NLRP3 Inflammasome in Neutrophil Extracellular Trap Formation.ImmunoHorizons · 2024Article
- The gasdermin family: emerging therapeutic targets in diseases.Signal transduction and targeted therapy · 2024Review
- Gasdermin-E-Dependent Non-Canonical Pyroptosis Promotes Drug-Induced Liver Failure by Promoting CPS1 deISGylation and Degradation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation.Nature communications · 2024Article
- Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death.Nature communications · 2024Article
- NLRP6 negatively regulates host defense against polymicrobial sepsis.Frontiers in immunology · 2024Article
- Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire.Seminars in immunology · 2023Review
- Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways.Immunological reviews · 2023Review
- Gasdermins in sepsis.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Fei LiuState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, CAMS Key Laboratory for Prevention and Control of Hematological Disease Treatment Related Infection, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.ORCID 0000-0002-5960-9166
Laxman GhimireDepartment of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA.
Arumugam BalasubramanianDepartment of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-7333-8542
Alan Y HsuDepartment of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA.
Zhaoran ZhangState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, CAMS Key Laboratory for Prevention and Control of Hematological Disease Treatment Related Infection, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Hongbo YuDepartment of Pathology and Laboratory Medicine, VA Boston Healthcare System, Boston, MA.
Fengxia MaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, CAMS Key Laboratory for Prevention and Control of Hematological Disease Treatment Related Infection, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Hongbo R LuoDepartment of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-8545-0451
Funding
Transcription regulation in hematopoiesisP01HL095489 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PARK, SHINYOUNG · 2010 to 2020
$20.1MNovel Strategies to Improve Blood Transfusion PracticeP01HL158688 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Hongbo R Luo · 2022 to 2026
$12.9MEnhancing neutrophil function in neutropenia-related pneumoniaR01HL092020 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI LUO, HONGBO R · 2009 to 2022
$5.2MRegulation of neutrophil death by GSDMD in Candida albicans infectionR01AI145274 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2023
$2.2MRegulation of IL-1β bioactivity by Cysteine S-glutathionylationR01AI142642 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2023
$2.2MCell-based high-throughput chemical genetic screening for GSDMD inhibitorsR01AI141386 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2022
$1.8MNHLBI NIH HHS P01 HL095489NHLBI NIH HHS P01 HL158688NHLBI NIH HHS R01 HL092020NIAID NIH HHS R01 AI141386NIAID NIH HHS R01 AI142642NIAID NIH HHS R01 AI145274
Abstract
PubMed holds no abstract for this paper.
Indexed as
NeutrophilsSepsisAnimalsApoptosis Regulatory ProteinsGasderminsHumansIntracellular Signaling Peptides and ProteinsMiceApoptosis Regulatory ProteinsGasderminsIntracellular Signaling Peptides and Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.