ArticlePloS one2022
A coupled atrioventricular-aortic setup for in-vitro hemodynamic study of the systemic circulation: Design, fabrication, and physiological relevancy.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Aortic Longitudinal Stretch and Recoil Affect Cerebral Perfusion: Insights from a Physiologically Accurate In-Vitro Experiment Model.Annals of biomedical engineering · 2026Article
- Compliance modulation of a soft robotic atrioventricular model of heart failure with preserved ejection fraction.Nature communications · 2026Article
- Assessment of Myocardial Injury Size Metrics Using Carotid Pressure Waveform: Proof-of-Concept in Coronary Occlusion/Reperfusion Rat Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Time-frequency machine learning transfer function for central pressure waveforms.European heart journal open · 2025Article
- A spectral machine learning approach to derive central aortic pressure waveforms from a brachial cuff.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Aortic stretch and recoil create wave-pumping effect: the second heart in the systemic circulation.Journal of the Royal Society, Interface · 2025Article
- Technological evolution ofFrontiers in physiology · 2025Review
- A preoperative planning procedure of septal myectomy for hypertrophic obstructive cardiomyopathy using image-based computational fluid dynamics simulations and shape optimization.Scientific reports · 2024Article
- Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies.Journal of the American Heart Association · 2024Article
- Assessing pressure wave components for aortic stiffness monitoring through spectral regression learning.European heart journal open · 2024Article
- Article
- Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system.American journal of physiology. Heart and circulatory physiology · 2023Article
- Instantaneous detection of acute myocardial infarction and ischaemia from a single carotid pressure waveform in rats.European heart journal open · 2023Article
- On the Longitudinal Wave Pumping in Fluid-filled Compliant Tubes.Physics of fluids (Woodbury, N.Y. : 1994) · 2023Article
- Non-Invasive Pressure-Only Aortic Wave Intensity Evaluation Using Hybrid Fourier Decomposition-Machine Learning Approach.IEEE transactions on bio-medical engineering · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In-vitro models of the systemic circulation have gained a lot of interest for fundamental understanding of cardiovascular dynamics and for applied hemodynamic research. In this study, we introduce a physiologically accurate in-vitro hydraulic setup that models the hemodynamics of the coupled atrioventricular-aortic system. This unique experimental simulator has three major components: 1) an arterial system consisting of a human-scale artificial aorta along with the main branches, 2) an artificial left ventricle (LV) sac connected to a programmable piston-in-cylinder pump for simulating cardiac contraction and relaxation, and 3) an artificial left atrium (LA). The setup is designed in such a way that the basal LV is directly connected to the aortic root via an aortic valve, and to the LA via an artificial mitral valve. As a result, two-way hemodynamic couplings can be achieved for studying the effects that the LV, aorta, and LA have on each other. The collected pressure and flow measurements from this setup demonstrate a remarkable correspondence to clinical hemodynamics. We also investigate the physiological relevancies of isolated effects on cardiovascular hemodynamics of various major global parameters found in the circulatory system, including LV contractility, LV preload, heart rate, aortic compliance, and peripheral resistance. Subsequent control over such parameters ultimately captures physiological hemodynamic effects of LV systolic dysfunction, preload (cardiac) diseases, and afterload (arterial) diseases. The detailed design and fabrication of the proposed setup is also provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.