Evidence map›Paper›PMID 36331675›Full record

ArticleInvestigational new drugs2023

The influence of verapamil on the pharmacokinetics of the pan-HER tyrosine kinase inhibitor neratinib in rats: the role of P-glycoprotein-mediated efflux.

Defei Qi, Yuanyuan Dou, Wenke Zhang, Mengqing Wang, Yingying Li, Mingzhu Zhang, Jia Qin, Jinlan Cao, Dong Fang, Jing Ma and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Investigational new drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Defei Qi *School of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Yuanyuan Dou *School of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Wenke ZhangSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Mengqing WangSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Yingying LiSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Mingzhu ZhangSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Jia QinSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Jinlan CaoSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Dong FangAcademy for Advanced Interdisciplinary Studies, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Jing MaSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China.
Wei YangGuangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research), Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd, Guangzhou, 510980, Guangdong, China.
Songqiang XieInstitute of Chemical Biology, School of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China. xiesq@henu.edu.cn.
Hua SunSchool of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, Henan, China. sunhua@vip.henu.edu.cn.
Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neratinib, an irreversible pan-HER tyrosine kinase inhibitor, has been approved for the treatment of HER2-positive (HER2

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Tyrosine Kinase InhibitorsAnimalsATP Binding Cassette Transporter, Subfamily BChromatography, LiquidDogsHumansQuinolinesRatsTandem Mass SpectrometryVerapamilATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1neratinibQuinolinesTyrosine Kinase InhibitorsVerapamilMDCK cellsNeratinibP-glycoproteinPharmacokineticsUPLC-MS/MS

Identifiers

PMID36331675
OpenAlexW4308186196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.