Evidence map›Paper›PMID 36331612›Full record

Observational studyActa neurochirurgica2022

Dynamics in cognition and health-related quality of life in grade 2 and 3 gliomas after surgery.

Teodor Svedung Wettervik, Åsa A Munkhammar, Malin Jemstedt, Marcus Ersson, Francesco Latini, Mats Ryttlefors, Maria Zetterling

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta neurochirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Multidisciplinary Management of Isocitrate Dehydrogenase-Mutated Gliomas in a Contemporary Molecularly Defined Era.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Teodor Svedung WettervikSection of Neurosurgery, Department of Medical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden. teodor.svedung-wettervik@neuro.uu.se.ORCID http://orcid.org/0000-0002-4556-5721
Åsa A MunkhammarSection of Neurosurgery, Department of Medical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.
Malin JemstedtSection of Neurosurgery, Department of Medical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.
Marcus ErssonSection of Neurosurgery, Department of Medical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.
Francesco LatiniSection of Neurosurgery, Department of Medical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.
Mats RyttleforsSection of Neurosurgery, Department of Medical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.
Maria ZetterlingSection of Neurosurgery, Department of Medical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe focus of clinical management and research in gliomas has been on survival, but the interest in the treatment effects on cognition and health-related quality of life (HRQoL) is emerging. The primary aim of this study was to investigate the dynamics in cognition after brain tumor surgery for astrocytomas and oligodendrogliomas grade 2 and 3. The secondary aim was to investigate the association of postoperative changes in cognition with changes HRQoL.

methodsIn this observational study, 48 patients operated for an astrocytoma or oligodendrogliomas, grade 2 or 3, at the Department of Neurosurgery, Uppsala, Sweden, 2016-2021, were included. Cognitive and language skills were assessed with a selected test battery and HRQoL was patient-reported as assessed with RAND-36 pre- and approximately 3 months postoperatively.

resultsThere was a significant postoperative decrease in attention span and verbal learning, but the patients improved in the test for visual memory. There was no change in visual attention, executive function, verbal memory, visual organization and construction, verbal fluency, and confrontation naming. The RAND-36 variables physical function, role physical, general health, vitality, and social functioning decreased significantly after surgery. Patients operated for tumor recurrence exhibited greater deterioration in attention and a greater extent of resection correlated with a less pronounced decrease in verbal memory, but there were otherwise weak associations between the dynamics in cognition and patient-, tumor-, and treatment-variables. A decline in cognitive variables was not associated with worse HRQoL.

conclusionsAlthough both several cognitive and HRQoL domains deteriorated postoperatively, these changes did not correlate with each other. This highlights the complexity of cognitive and HRQoL dynamics in the early postoperative phase.

Indexed as

AstrocytomaBrain NeoplasmsCognition DisordersGliomaOligodendrogliomaCognitionHumansNeoplasm Recurrence, LocalNeuropsychological TestsQuality of LifeAstrocytomaBrain tumorCognitionHealth-related quality of lifeLow-grade gliomaOligodendroglioma

Identifiers

PMID36331612
PMCPMC9705489
OpenAlexW4308186894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.