Evidence map›Paper›PMID 36331552›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Magnesium homeostasis in deoxygenated sickle erythrocytes is modulated by endothelin-1 via Na

José R Romero, Yaritza Inostroza-Nieves, Patricia Pulido-Perez, Pablo Lopez, Jay G Wohlgemuth, Jeffrey S Dlott, L Michael Snyder, Seth L Alper, Alicia Rivera

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Magnesium homeostasis in deoxygenated sickle erythrocytes is modulated by endothelin-1 via NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

José R RomeroDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Yaritza Inostroza-NievesDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Patricia Pulido-PerezDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Pablo LopezDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Jay G WohlgemuthQuest Diagnostics, Secaucus, New Jersey, USA.
Jeffrey S DlottQuest Diagnostics, Secaucus, New Jersey, USA.
L Michael SnyderQuest Diagnostics, Secaucus, New Jersey, USA.
Seth L AlperDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-6228-2512
Alicia RiveraDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-0433-6367
Brigham and Women's Hospital · USQuest Diagnostics (United States) · USBeth Israel Deaconess Medical Center · USBoston Children's Hospital · US

Funding

Aldosteron, Intracellular Leukocyte Magnesium and Inflammation in DiabetesR01HL096518 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROMERO, JOSE R · 2009 to 2012
$1.9M
Mechanisms of Endothelin 1-Induced Sickle Cell PathologyR01HL090632 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI RIVERA, ALICIA · 2008 to 2011
$1.8M
CELLULAR MAGNESIUM DYSFUNCTION IN DIABETESR03DK064841 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ROMERO, JOSE R · 2003 to 2005
$519k
CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASEK01HL067699 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI RIVERA, ALICIA · 2001 to 2003
$417k
NHLBI NIH HHS K01 HL067699NHLBI NIH HHS R01 HL090632NHLBI NIH HHS R01 HL096518NIDDK NIH HHS R03 DK064841
6 · The paper itself

Abstract

Painful crises in sickle cell disease (SCD) are associated with increased plasma cytokines levels, including endothelin-1 (ET-1). Reduced red cell magnesium content, mediated in part by increased Na

Indexed as

Anemia, Sickle CellEndothelin-1AnimalsDehydrationErythrocytesHomeostasisMagnesiumMiceMice, Inbred C57BLMice, TransgenicReceptor, Endothelin BSodiumEndothelin-1MagnesiumReceptor, Endothelin BSodium

Identifiers

PMID36331552
PMCPMC9703344
OpenAlexW4308210158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.