Evidence map›Paper›PMID 36331248›Full record

ArticleJCO precision oncology2022

A Case of Sustained Tumor Regression With MP0274, a Novel DARPin Therapeutic Targeting Human Epidermal Growth Factor Receptor 2 Signaling, in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Prior Trastuzumab and Pertuzumab.

Stefanie Fischer, Thorsten O Götze, Aurelius Omlin, Richard D Baird, Keith M Dawson, Christof Zitt, Zita Arany, Gaby Tresch, Ulrike Fiedler, Simone Jeger and 5 more

Abstract readCase Reports
In one paragraph

Article in JCO precision oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stefanie FischerKantonsspital St Gallen, Klinik für Medizinische Onkologie und Hämatologie, St Gallen, Switzerland.ORCID 0000-0001-9609-3640
Thorsten O GötzeKrankenhaus Nordwest GmbH, Institut für Klinisch-Onkologische Forschung, Frankfurt, Germany.
Aurelius OmlinKantonsspital St Gallen, Klinik für Medizinische Onkologie und Hämatologie, St Gallen, Switzerland.ORCID 0000-0002-4783-4788
Richard D BairdCancer Research UK Cambridge Centre, Cambridge, United Kingdom.ORCID 0000-0001-7071-6483
Keith M DawsonMolecular Partners AG, Schlieren, Switzerland.ORCID 0000-0002-1770-291X
Christof ZittMolecular Partners AG, Schlieren, Switzerland.
Zita AranyMolecular Partners AG, Schlieren, Switzerland.
Gaby TreschMolecular Partners AG, Schlieren, Switzerland.
Ulrike FiedlerMolecular Partners AG, Schlieren, Switzerland.
Simone JegerMolecular Partners AG, Schlieren, Switzerland.
Samson FungFung Consulting, Eching, Germany.ORCID 0000-0003-1079-9090
Philippe LegenneMolecular Partners AG, Schlieren, Switzerland.
Nicolas LeupinMolecular Partners AG, Schlieren, Switzerland.
Andreas SchneeweissNational Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-2429-4512
Carlo FremdNational Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-7840-430X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsBreast NeoplasmsAntibodies, Monoclonal, HumanizedDesigned Ankyrin Repeat ProteinsErb-b2 Receptor Tyrosine KinasesFemaleHumansTrastuzumabAntibodies, Monoclonal, HumanizedAntineoplastic AgentsDesigned Ankyrin Repeat ProteinsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasespertuzumabTrastuzumab

Identifiers

PMID36331248
PMCPMC9666114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.