Evidence map›Paper›PMID 36331157›Full record

ArticleThe Journal of urology2023

Radioisotope-guided Lymphadenectomy for Pelvic Lymph Node Staging in Patients With Intermediate- and High-risk Prostate Cancer (The Prospective SENTINELLE Study).

François Lannes, Michael Baboudjian, Alain Ruffion, Mathieu Rouy, Francesco Giammarile, Thierry Rousseau, Françoise Kraeber-Bodéré, Caroline Rousseau, Daniela Rusu, Mathilde Colombié and 4 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in The Journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02732392 (Validation of Radioisotope Guided Lymphadenectomy for Loco-regional Staging in Patients With Intermediate or High-risk Prostate Cancer), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02732392 nacompletednot on this map

Validation of Radioisotope Guided Lymphadenectomy for Loco-regional Staging in Patients With Intermediate or High-risk Prostate Cancer

TypeinterventionalSponsorAssistance Publique Hopitaux De MarseilleRan2013 to 2023Enrolled177ConditionsPatient With Prostate CancerArmsstandard lymphadenectomy, lymphadenectomy radio-isotope method
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Open veterinary journal · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 5 countries.

François LannesDepartment of Urology, North Hospital, Aix-Marseille University, APHM, Marseille, France.
Michael BaboudjianDepartment of Urology, North Hospital, Aix-Marseille University, APHM, Marseille, France.
Alain RuffionDepartment of Urology, Hospices Civils de Lyon, Lyon, France.
Mathieu RouyAix-Marseille University, Marseille, France.
Francesco GiammarileNuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
Thierry RousseauDepartment of Urology, Clinique Urologie Nantes Atlantis, Saint Herblain, France.
Françoise Kraeber-BodéréNantes University, CHU Nantes, CNRS, Inserm, CRCINA, Nantes, France.
Caroline RousseauNantes University, CHU Nantes, CNRS, Inserm, CRCINA, Nantes, France.
Daniela RusuNantes University, CHU Nantes, CNRS, Inserm, CRCINA, Nantes, France.
Mathilde ColombiéNantes University, CHU Nantes, CNRS, Inserm, CRCINA, Nantes, France.
Isabelle Brenot-RossiDepartment of Nuclear Medicine, Institut Paoli-Calmettes, Marseille, France.
Dominique RossiDepartment of Urology, North Hospital, Aix-Marseille University, APHM, Marseille, France.
Nicolas MottetDepartment of Urology, University Jean Monnet, St Etienne, France.
Cyrille BastideDepartment of Urology, North Hospital, Aix-Marseille University, APHM, Marseille, France.
Aix-Marseille Université · FRNantes Université · FRCentre National de la Recherche Scientifique · FRHospices Civils de Lyon · FRIMT Atlantique · FRInserm · FRInstitut Paoli-Calmettes · FRInternational Atomic Energy Agency · ATUniversitat de Barcelona · ESUniversité Jean Monnet · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur aim was to prospectively evaluate the diagnostic accuracy of sentinel lymph node biopsy-guided lymph node dissection compared to extended pelvic lymph node dissection in patients with intermediate- or high-risk prostate cancer. MATERIALS AND

methodsWe conducted a prospective, single-arm, multicenter study at 3 tertiary centers in France between February 2012 and May 2019. Eligible patients had clinically localized intermediate- or high-risk prostate cancer. After intraprostatic injection of (99m)Tc-nanocolloid, the locations of the sentinel lymph nodes were defined by preoperative lymphoscintigraphy. Surgical excision of the sentinel lymph nodes was performed using intraoperative gamma probe guidance. After resection of the sentinel lymph nodes, extended pelvic lymph node dissection was performed in all patients. We assessed the diagnostic accuracy of the sentinel lymph node biopsy method using extended pelvic lymph node dissection as the reference standard. This trial was registered in ClinicalTrials.gov (NCT02732392).

resultsA total of 162 men cN0M0 (CT scan and bone scan) were enrolled: 106 (65.4%) and 56 (34.6%) patients had intermediate- and high-risk prostate cancer, respectively. The median number of nodes retrieved was 14 (mean 16, IQR 10-21) per patient. At final pathological analysis, 22 patients (13.6%) were pN+. Sensitivity, specificity, negative predictive value, and positive predictive value of sentinel lymph node biopsy method in detecting patients with at least 1 lymph node metastasis were 95.4% (95% CI, 75.1-99.7), 100% (95% CI, 96.6-100), 99.2% (95% CI, 95.5-99.9), and 100% (95% CI, 80.7-100), respectively.

conclusionsOur multicenter prospective study supports that sentinel lymph node biopsy is a very effective and sensitive method for pelvic lymph node staging in patients with intermediate- or high-risk localized prostate cancer.

Indexed as

Prostatic NeoplasmsHumansLymph Node ExcisionLymph NodesMaleNeoplasm StagingProspective StudiesRadioisotopesSentinel Lymph Node BiopsyRadioisotopeslymph node excisionprostatic neoplasmssentinel lymph node

Identifiers

PMID36331157
OpenAlexW4308182910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.