Evidence map›Paper›PMID 36331101›Full record

ArticleArthritis care & research2023

A Narrowing Mortality Gap: Temporal Trends of Cause-Specific Mortality in a National Matched Cohort Study in US Veterans With Rheumatoid Arthritis.

Tate M Johnson, Yangyuna Yang, Punyasha Roul, Brian C Sauer, Grant W Cannon, Gary Kunkel, Kaleb Michaud, Joshua F Baker, Ted R Mikuls, Bryant R England

Open access · greenAbstract read
In one paragraph

Article in Arthritis care & research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tate M JohnsonVA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0003-0335-4157
Yangyuna YangUniversity of Nebraska Medical Center, Omaha.
Punyasha RoulUniversity of Nebraska Medical Center, Omaha.
Brian C SauerSalt Lake City VA Medical Center and University of Utah, Salt Lake City.ORCID 0000-0002-3546-3051
Grant W CannonSalt Lake City VA Medical Center and University of Utah, Salt Lake City.ORCID 0000-0001-6640-9173
Gary KunkelSalt Lake City VA Medical Center and University of Utah, Salt Lake City.
Kaleb MichaudUniversity of Nebraska Medical Center, Omaha, and FORWARD, the National Data Bank for Rheumatic Diseases, Wichita, Kansas.
Joshua F BakerCorporal Michael J. Crescenz VA Medical Center and University of Pennsylvania, Philadelphia.
Ted R MikulsVA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0002-0897-2272
Bryant R EnglandVA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0002-9649-3588
University of Utah · USVA Nebraska Western Iowa Health Care System · USUniversity of Nebraska Medical Center · USPhiladelphia VA Medical Center · USThe National Databank for Rheumatic Diseases · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUDA, CHITTIBABU · 2016 to 2025
$42.8M
Pathogenic Role of Malondialdehyde-Acetaldehyde Adducts in Rheumatoid ArthritisI01BX004660 · VA · OMAHA VA MEDICAL CENTER · PI MIKULS, TED RICHARD · 2020 to 2023
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Adipokines as Biomarkers of Cachexia and High-Risk Rheumatoid ArthritisI01CX001703 · VA · PHILADELPHIA VA MEDICAL CENTER · PI BAKER, JOSHUA F. · 2019 to 2023
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Improving the Management of Rheumatoid Arthritis-Associated Lung Disease in Veterans Using Real-World DataIK2CX002203 · VA · OMAHA VA MEDICAL CENTER · PI Bryant R England · 2021 to 2026
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BLRD VA I01 BX004660CSRD VA I01 CX001703CSRD VA IK2 CX002203NIGMS NIH HHS U54 GM115458RRD VA I01 RX003644
6 · The paper itself

Abstract

objectiveTo examine temporal trends in all-cause and cause-specific mortality in patients with rheumatoid arthritis (RA) in the Veterans Health Administration (VHA).

methodsWe conducted a matched cohort study in the VHA from January 1, 2000 to December 31, 2017. Incident RA patients were matched up to 1:10 on age, sex, and VHA enrollment year to non-RA patients, then followed until death or end of study period. Cause of death was obtained from the National Death Index. Multivariable Cox regression models stratified by RA diagnosis years were used to examine trends in RA-related risk of all-cause and cause-specific mortality.

resultsAmong 29,779 incident RA patients (matched to 245,226 non-RA patients), 9,565 deaths occurred. RA patients were at increased risk of all-cause (adjusted hazard ratio [HR

conclusionExcess RA-related mortality was driven by cardiovascular, cancer, respiratory, and infectious causes, particularly cardiopulmonary diseases. Although our findings support that RA-related mortality risk is decreasing over time, a mortality gap remains for all-cause and cause-specific mortality in RA.

Indexed as

Arthritis, RheumatoidCardiovascular DiseasesNeoplasmsVeteransCause of DeathCohort StudiesHumansRisk Factors

Identifiers

PMID36331101
PMCPMC10275614
OpenAlexW4308187686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.