Evidence map›Paper›PMID 36331083›Full record

ArticleBone & joint research2022

Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase : a novel approach in the prevention of osteoclastogenesis.

Yihe Zhang, Bingjie Jiang, Pengyuan Zhang, Sung K Chiu, Meng H Lee

Open access · goldAbstract read
In one paragraph

Article in Bone & joint research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yihe ZhangDepartment of Biological Sciences/Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.ORCID 0000-0003-4937-7354
Bingjie JiangDepartment of Biological Sciences/Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Pengyuan ZhangDepartment of Biological Sciences/Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.ORCID 0000-0002-5580-2145
Sung K ChiuShanghai XP Biomed Ltd, Shanghai, China.ORCID 0000-0002-9927-7346
Meng H LeeDepartment of Biological Sciences/Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.ORCID 0000-0002-2727-3565
Xi’an Jiaotong-Liverpool University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTissue inhibitors of metalloproteinases (TIMPs) are the endogenous inhibitors of the zinc-dependent matrix metalloproteinases (MMP) and A disintegrin and metalloproteinases (ADAM) involved in extracellular matrix modulation. The present study aims to develop the TIMPs as biologics for osteoclast-related disorders.

methodsWe examine the inhibitory effect of a high affinity, glycosyl-phosphatidylinositol-anchored TIMP variant named 'T1

resultsOsteoclast progenitor cells transduced with T1

conclusionT1

Indexed as

Cathepsin Kextracellular matrixmatrix metalloproteinases (MMP)mRNAOsteoclastogenesisosteoclastsOsteoclastsosteoporosisprogenitor cellsRNAstainingtartrate-resistant acid phosphataseTIMPtissue inhibitors of metalloproteinases (TIMPs)TRAP

Identifiers

PMID36331083
PMCPMC9680204
OpenAlexW4308185842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.