Evidence map›Paper›PMID 36331061›Full record

ArticleLab on a chip2022

Deep learning-assisted sensitive detection of fentanyl using a bubbling-microchip.

Hui Chen, Sungwan Kim, Joseph Michael Hardie, Prudhvi Thirumalaraju, Supriya Gharpure, Sahar Rostamian, Srisruthi Udayakumar, Qingsong Lei, Giwon Cho, Manoj Kumar Kanakasabapathy and 1 more

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
  2. Article
  3. Human Embryo Quality Assessment with Deep Learning Models.Journal of obstetrics and gynaecology of India · 2025
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hui ChenDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.ORCID 0000-0002-9422-8959
Sungwan KimDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.ORCID 0000-0001-8090-199X
Joseph Michael HardieDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.
Prudhvi ThirumalarajuDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.
Supriya GharpureDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.ORCID 0000-0003-3169-3906
Sahar RostamianDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.ORCID 0000-0003-4182-6004
Srisruthi UdayakumarDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.ORCID 0000-0002-3892-7579
Qingsong LeiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.ORCID 0000-0001-7124-5396
Giwon ChoDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.
Manoj Kumar KanakasabapathyDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.
Hadi ShafieeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, Massachusetts 02139, USA. hshafiee@bwh.harvard.edu.ORCID 0000-0003-2240-7648
Brigham and Women's Hospital · US

Funding

A smartphone-enabled point-of-care HCV Ag diagnostic using catalytic nanoparticles and AI-enhanced image processingR01EB033866 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2022 to 2025
$3.3M
Microchip for HBV testing using HIV-infected blood samplesR01AI138800 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2019 to 2023
$3.1M
A mobile health diagnostic device for HIV self-testingR33AI140489 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2022 to 2023
$1.8M
A mobile health diagnostic device for HIV self-testingR61AI140489 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2019 to 2021
$1.6M
NIAID NIH HHS R01 AI138800NIAID NIH HHS R33 AI140489NIAID NIH HHS R61 AI140489NIBIB NIH HHS R01 EB033866
6 · The paper itself

Abstract

Deep learning-enabled smartphone-based image processing has significant advantages in the development of point-of-care diagnostics. Conventionally, most deep-learning applications require task specific large scale expertly annotated datasets. Therefore, these algorithms are oftentimes limited only to applications that have large retrospective datasets available for network development. Here, we report the possibility of utilizing adversarial neural networks to overcome this challenge by expanding the utility of non-specific data for the development of deep learning models. As a clinical model, we report the detection of fentanyl, a small molecular weight drug that is a type of opioid, at the point-of-care using a deep-learning empowered smartphone assay. We used the catalytic property of platinum nanoparticles (PtNPs) in a smartphone-enabled microchip bubbling assay to achieve high analytical sensitivity (detecting fentanyl at concentrations as low as 0.23 ng mL

Indexed as

Deep LearningMetal NanoparticlesAlgorithmsFentanylHumansImage Processing, Computer-AssistedPlatinumRetrospective StudiesFentanylPlatinum

Identifiers

PMID36331061
PMCPMC9710303
OpenAlexW4308184368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.