Evidence map›Paper›PMID 36330863›Full record

ArticleJournal of veterinary internal medicine2022

Clinical characterization of epileptic seizures in Pomeranians with idiopathic epilepsy or epilepsy of unknown cause.

Yoshihiko Yu, Daisuke Hasegawa, Shinichi Kanazono, Miyoko Saito

Abstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  6. Electroencephalography: electrode arrays in dogs.Frontiers in veterinary science · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoshihiko YuLaboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Tokyo, Japan.ORCID https://orcid.org/0000-0003-3396-6525
Daisuke HasegawaLaboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-7554-9108
Shinichi KanazonoNeurology and Neurosurgery Service, Veterinary Specialists & Emergency Center, Saitama, Japan.ORCID https://orcid.org/0000-0002-4960-2390
Miyoko SaitoLaboratory of Small Animal Surgery (Neurology), School of Veterinary Medicine, Azabu University, Kanagawa, Japan.ORCID https://orcid.org/0000-0001-6560-070X

Funding

The Science Research Promotion Fund from the Promotion and Mutual Aid Corporation for Private School of Japan (PMAC) 2022-16
6 · The paper itself

Abstract

backgroundFocal epileptic motor seizures manifested by limb contraction have been recognized anecdotally in Pomeranians.

objectivesTo investigate clinical features of idiopathic epilepsy (IE) and epilepsy of unknown cause (EUC) in Pomeranians as well as the ADAM23 haplotype frequency previously reported as a common risk haplotype for epilepsy in several breeds of dogs. ANIMALS: Twenty-eight Pomeranians, including 15 with IE and 13 with EUC. Nine Pomeranians with epilepsy and 8 control Pomeranians were used for ADAM23 risk haplotype analysis.

methodsCase series study including both retrospectively and prospectively collected cases. The ADAM23 haplotype was determined by direct sequencing of PCR amplicons. Data were analyzed descriptively.

resultsFocal epileptic seizures (FS) were the predominant type of seizure in 22 of 28 dogs (78.6%). Among these, 12 of the IE dogs (80.0%) and 10 of the EUC dogs (76.9%) showed FS. Notably, 21 of 22 Pomeranians with FS (95.5%) showed limb contraction during ictal periods. Some dogs with FS also showed immobility, generalized tremors, difficulty walking or moving, autonomic signs, orofacial automatisms or some combination during ictal events. Ten dogs with FS and limb contraction had electroencephalography (EEG) performed, and interictal epileptiform discharges were identified in 9 dogs. The haplotype frequency of ADAM23 in cases was lower (27.8%) than that of the controls (56.3%). CONCLUSIONS AND CLINICAL IMPORTANCE: In our study, FS was the predominant type of seizure in Pomeranians, and almost all cases with FS showed limb contraction, regardless of whether having IE or EUC.

Indexed as

Dog DiseasesEpilepsies, PartialEpilepsyAnimalsDogsElectroencephalographyRetrospective StudiesSeizurescanineelectroencephalographyfocal motor seizureseizure phenomenologyseizure semiology

Identifiers

PMID36330863
PMCPMC9708448

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.