SynthesisPediatrics2022
Preterm Brain Injury and Neurodevelopmental Outcomes: A Meta-analysis.
Synthesis in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Cerebral near-infrared spectroscopy monitoring for prevention of death or neurodevelopmental disability in very preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Indications and timings for caffeine initiation in preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Neonatal intracranial pathologies on ultrasound imaging in sub-Saharan Africa: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- School-age outcomes of children after perinatal brain injury: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- The MIND Randomized Controlled Trial: An Intervention to Improve Neural Speech Processing and 2-Year Language Outcomes of Infants Born Preterm.The Journal of pediatrics · 2026Trial
- Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.JAMA pediatrics · 2026Trial
- Neurodevelopmental Outcomes of Very Low Birth Weight Infants Following Extrauterine Placental Perfusion: A Follow-Up Study.Acta paediatrica (Oslo, Norway : 1992) · 2025Trial
- Risk Factors Influencing Neurodevelopmental Outcome and Survival in Preterm Infants: A Prospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Recorded Contingent Caregiver Voice Independently Improves Neural Speech Processing in Hospitalized Preterm Infants: A Multisite Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Weighted and unweighted comorbidity burden for predicting three-year neurodevelopment in extremely preterm infants: A nationwide cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Beyond Maximum Haemorrhage Grade: Serial Cranial Ultrasound Phenotyping Refines Developmental Risk Stratification After Intraventricular Haemorrhage in Very Preterm Infants.Journal of clinical medicine · 2026Article
- Risk factors and timing of ocular complications after screening for retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Cranial Ultrasound Morphometry and Head Circumference at Term-Equivalent Age Are Associated with Early Neurodevelopmental Outcomes in Preterm Infants.Medicina (Kaunas, Lithuania) · 2026Observational
- Risk profiles of motor deficits in preterm infants: a cluster analysis approach.Pediatric research · 2026Article
- Grape Seed Proanthocyanidin Extract (GSPE) Mitigates Preterm White Matter Injury in Mice Via Improving Mitochondrial Homeostasis and Activity of IMMP2L-Related Signaling Pathway.Neurochemical research · 2026Article
- Inpatient morbidities and medical technology use at 2 years among extremely preterm infants.Pediatric research · 2026Observational
- Best evidence summary for the prevention of intraventricular hemorrhage in preterm infants: a systematic review.Translational pediatrics · 2026Review
- Exploring hemoglobin dynamics and scavenging mechanisms in preterm infants and preterm rabbits with cerebral intraventricular hemorrhage.Pediatric research · 2026Article
- Early soluble LOX-1, cerebral perfusion, and intrauterine inflammation in very and extremely preterm infants.Pediatric research · 2026Observational
- Inosine Ameliorates the Injurious Microenvironment for Oligodendrocyte Precursor Cells by Suppressing Microglial Activation and Neuroinflammation In Vitro.Neurochemical research · 2026Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
contextPreterm brain injuries are common; neurodevelopmental outcomes following contemporary neonatal care are continually evolving.
objectiveTo systematically review and meta-analyze neurodevelopmental outcomes among preterm infants after intraventricular hemorrhage (IVH) and white matter injury (WMI). DATA SOURCES: Published and grey literature were searched across 10 databases between 2000 and 2021. STUDY SELECTION: Observational studies reporting 3-year neurodevelopmental outcomes for preterm infants with IVH or WMI compared with preterm infants without injury. DATA EXTRACTION: Study characteristics, population characteristics, and outcome data were extracted.
resultsThirty eight studies were included. There was an increased adjusted risk of moderate-severe neurodevelopmental impairment after IVH grade 1 to 2 (adjusted odds ratio 1.35 [95% confidence interval 1.05-1.75]) and IVH grade 3 to 4 (adjusted odds ratio 4.26 [3.25-5.59]). Children with IVH grade 1 to 2 had higher risks of cerebral palsy (odds ratio [OR] 1.76 [1.39-2.24]), cognitive (OR 1.79 [1.09-2.95]), hearing (OR 1.83 [1.03-3.24]), and visual impairment (OR 1.77 [1.08-2.9]). Children with IVH grade 3 to 4 had markedly higher risks of cerebral palsy (OR 4.98 [4.13-6.00]), motor (OR 2.7 [1.52-4.8]), cognitive (OR 2.3 [1.67-3.15]), hearing (OR 2.44 [1.42-4.2]), and visual impairment (OR 5.42 [2.77-10.58]). Children with WMI had much higher risks of cerebral palsy (OR 14.91 [7.3-30.46]), motor (OR 5.3 [3-9.36]), and cognitive impairment (OR 3.48 [2.18-5.53]). LIMITATIONS: Heterogeneity of outcome data.
conclusionsMild IVH, severe IVH, and WMI are associated with adverse neurodevelopmental outcomes. Utilization of core outcome sets and availability of open-access study data would improve our understanding of the nuances of these outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.