Evidence map›Paper›PMID 36330561›Full record

ArticleCancer science2023

Comparison between renal pelvic and ureteral tumors in muscle-invasive upper tract urothelial carcinoma.

Chen Qiwei, Shi Jiajun, Liang Cheng, Huang Shengbo, Kuai Yue, Wang Shujing, Wenlong Liu, Zhu Xinqing, Wang Hongyu, Yang Deyong

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Chen QiweiDepartment of Urology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Shi JiajunDepartment of Urology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Liang ChengDepartment of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Huang ShengboSchool of Information and Communication Engineering, Dalian University of Technology, Dalian, China.
Kuai YueSchool of Information and Communication Engineering, Dalian University of Technology, Dalian, China.
Wang ShujingDepartment of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China.
Wenlong LiuSchool of Information and Communication Engineering, Dalian University of Technology, Dalian, China.
Zhu XinqingDepartment of Urology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Wang HongyuSchool of Information and Communication Engineering, Dalian University of Technology, Dalian, China.
Yang DeyongDepartment of Urology, First Affiliated Hospital, Dalian Medical University, Dalian, China.ORCID https://orcid.org/0000-0002-1643-5792
Dalian Medical University · CNDalian University of Technology · CNIndiana University – Purdue University Indianapolis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although renal pelvic and ureteral urothelial carcinoma share similarities in their origins, disparities on a genetic and clinical level make them divergent entities. Clinical information from the Surveillance, Epidemiology, and End Results (SEER) database was used to validate the characteristics and molecular subtypes using single-center data, which were compared between the two types of muscle-invasive tumors. Simultaneously, to expand the sample size for further verification, we explored a deep learning algorithm to correctly classify molecular subtypes from H&E histology slides. We suggested that the renal pelvic group might have a proclivity towards luminal and the ureter towards basal and P53-like. Furthermore, we explore the heterogeneity of matrix and immune tumor microenvironment, and the ureteral group had more immune cell infiltration and higher stiffness. Collectively, these results showed that muscle-invasive upper tract urothelial carcinoma exist in distinct properties of clinical characteristics, molecular subtype, and tumor microenvironment.

Indexed as

Carcinoma, Transitional CellKidney NeoplasmsUreteral NeoplasmsUrinary Bladder NeoplasmsHumansKidney PelvisMusclesTumor Microenvironmentdeep learningimmunitymechanicsmolecular subtypeUTUC

Identifiers

PMID36330561
PMCPMC9986090
OpenAlexW4308182153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.