ArticleFrontiers in immunology2022
Dietary Aflatoxin B1 attenuates immune function of immune organs in grass carp (Ctenopharyngodon idella) by modulating NF-κB and the TOR signaling pathway.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Nanotechnology-Based Immunostimulants in Aquaculture: Mechanisms, Advances and Practical Applications.Veterinary medicine and science · 2026Review
- Mycotoxins as an Underestimated Honeybee Stressor: Aflatoxin, Contaminated Pollen, and Colony-Level Risk.Biology · 2026Review
- Effects of Different Stocking Densities on Growth Performance, Stress Resistance, Antioxidant Capacity and Immunity of Grass Carp.Animals : an open access journal from MDPI · 2026Article
- Occurrence of mycotoxins in fish feed and its consequences for aquaculture with special regard to the role of insect products.Mycotoxin research · 2026Review
- Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression.Current issues in molecular biology · 2026Article
- Review
- Dietary melegueta seed powder modulates growth, hepatic function, and biomarkers to counteract aflatoxin B₁ toxicity in broilers.Mycotoxin research · 2025Article
- 4-Methylesculetin alleviated aflatoxin B1-induced liver injury and ferritinophagy through AMPK- TOR-Ulk axis in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Impact of Aflatoxins on the Digestive, Immune, and Nervous Systems: The Role of Microbiota and Probiotics in Toxicity Protection.International journal of molecular sciences · 2025Review
- Review
- An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells.PloS one · 2025Article
- Aflatoxin B1 decreased flesh flavor and inhibited muscle development in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Effects of Dietary Aflatoxin B1 on Hybrid Grouper (Aquaculture nutrition · 2024Article
- A Brief Review on Aflatoxicosis in Aquaculture With a Focus on Fish.Aquaculture nutrition · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aflatoxin B1 (AFB1) is kind of a common mycotoxin in food and feedstuff. Aquafeeds are susceptible to contamination of AFB1. In teleost fish, the spleen and head kidney are key immune organ. Moreover, the fish skin is a critical mucosal barrier system. However, there was little study on the effects of dietary AFB1 on the immune response of these immune organs in fish. This study aimed to explore the impacts of oral AFB1 on the immune competence and its mechanisms in the skin, spleen, and head kidney of grass carp. Our work indicated that dietary AFB1 reduced antibacterial compounds and immunoglobulins contents, and decreased the transcription levels of antimicrobial peptides in grass carp immune organs. In addition, dietary AFB1 increased the transcription levels of pro-inflammatory cytokines and reduced the transcription levels of anti-inflammatory cytokines in the grass carp immune organs, which might be regulated by NF-κB and TOR signaling, respectively. Meanwhile, we evaluated the content of AFB1 in the grass carp diet should not exceed 29.48 μg/kg diet according to the levels of acid phosphatase and lysozyme. In summary, dietary AFB1 impaired immune response in grass carp skin, spleen, and head kidney.
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