Evidence map›Paper›PMID 36330336›Full record

ArticleFrontiers in cell and developmental biology2022

Protective role of endorepellin in renal developmental programming.

Xiaoshan Tang, Manqing Sun, Qian Shen, Jia Rao, Xue Yang, Ye Fang, Tianchao Xiang, Shanshan Xue, Lei Sun, Hong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoshan TangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Manqing SunDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Qian ShenDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jia RaoDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xue YangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Ye FangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Tianchao XiangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Shanshan XueDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Lei SunInstitute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai, China.
Hong XuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse intrauterine and early postnatal environment cause reduced nephron endowment and subsequent hypertension, chronic kidney disease (CKD). Exploring modifiable approaches is particularly important to alleviate the global burden of CKD. Enhanced glomerular progenitor cell apoptosis is a major contributor to renal developmental programming. The differentially expressed protein perlecan, which we previously identified using proteomics, is an important extracellular matrix glycoprotein, and its domain V (endorepellin) can inhibit apoptosis through a paracrine form. In explanted mice embryonic metanephros, we found that endorepellin can rescue glomeruli-deficit phenotype resulting from malnutrition, and this protective effect was also verified

Indexed as

apopotosisendorepellinintrauterine growth restrictionnephron endowmentrenal development

Identifiers

PMID36330336
PMCPMC9624284

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.