Evidence map›Paper›PMID 36330329›Full record

ArticleFrontiers in cell and developmental biology2022

An old friend with a new face: YB-1 and its role in healthy pregnancy and pregnancy-associated complications.

Florence Fischer, Anne Schumacher, Nicole Meyer, Beate Fink, Mario Bauer, Violeta Stojanovska, Ana Claudia Zenclussen

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Florence FischerDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany.
Anne SchumacherDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany.
Nicole MeyerDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany.
Beate FinkDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany.
Mario BauerDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany.
Violeta StojanovskaDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany.
Ana Claudia ZenclussenDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By promoting tissue invasion, cell growth and angiogenesis, the Y-box binding protein (YB-1) became famous as multifunctional oncoprotein. However, this designation is telling only part of the story. There is one particular time in life when actual tumorigenic-like processes become undoubtedly welcome, namely pregnancy. It seems therefore reasonable that YB-1 plays also a crucial role in reproduction, and yet this biological aspect of the cold-shock protein has been overlooked for many years. To overcome this limitation, we would like to propose a new perspective on YB-1 and emphasize its pivotal functions in healthy pregnancy and pregnancy-related complications. Moreover, we will discuss findings obtained from cancer research in the light of reproductive events to elucidate the importance of YB-1 at the feto-maternal interface.

Indexed as

cold shock proteinimplantationpregnancytrophoblastYB-1 protein

Identifiers

PMID36330329
PMCPMC9624282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.