Evidence map›Paper›PMID 36330201›Full record

ArticleBiomicrofluidics2022

Design of a flexing organ-chip to model

Jonathan P McKinley, Andre R Montes, Maple N Wang, Anuya R Kamath, Gissell Jimenez, Jianhua Lim, Siddharth A Marathe, Mohammad R K Mofrad, Grace D O'Connell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomicrofluidics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan P McKinleyDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, California 94720, USA.ORCID 0000-0003-3012-4453
Andre R MontesDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, California 94720, USA.ORCID 0000-0003-1123-2870
Maple N WangDepartment of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA.ORCID 0000-0001-5527-6678
Anuya R KamathDepartment of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA.
Gissell JimenezDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, California 94720, USA.
Jianhua LimDepartment of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA.
Siddharth A MaratheDepartment of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA.
Mohammad R K MofradDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, California 94720, USA.ORCID 0000-0001-7004-4859
Grace D O'ConnellDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, California 94720, USA.ORCID 0000-0003-0746-1638

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The leading cause of disability of all ages worldwide is severe lower back pain. To address this untreated epidemic, further investigation is needed into the leading cause of back pain, intervertebral disc degeneration. In particular, microphysiological systems modeling critical tissues in a degenerative disc, like the annulus fibrosus (AF), are needed to investigate the effects of complex multiaxial strains on AF cells. By replicating these mechanobiological effects unique to the AF that are not yet understood, we can advance therapies for early-stage degeneration at the cellular level. To this end, we designed, fabricated, and collected proof-of-concept data for a novel microphysiological device called the flexing annulus-on-a-chip (AoC). We used computational models and experimental measurements to characterize the device's ability to mimic complex physiologically relevant strains. As a result, these strains proved to be controllable, multi-directional, and uniformly distributed with magnitudes ranging from

Identifiers

PMID36330201
PMCPMC9625834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.