ArticleAmerican heart journal plus : cardiology research and practice2022
Sex differences in aortic stenosis: Identification of knowledge gaps for sex-specific personalized medicine.
Article in American heart journal plus : cardiology research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Reverse left ventricular remodeling after aortic valve replacement for aortic stenosis: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Sex differences in cardiac structure and function following ST-segment elevation myocardial infarction.Scientific reports · 2026Trial
- Temporal Trends in Hospitalization and Interventions for Aortic Stenosis in Canada, 2012-2024.CJC open · 2026Article
- Mitral Regurgitation after TAVR: Sex Differences and Low-Flow Low-Gradient Aortic Stenosis.JACC. Advances · 2026Article
- Women's heart and echocardiography.Journal of cardiovascular imaging · 2026Review
- A Review of Sex Differences in Patients with Aortic Stenosis: A Focus on Diagnostic and Treatment Differences, a Narrative Review.Journal of clinical medicine · 2026Review
- Sex differences in echocardiographic left ventricular remodeling and clinical outcomes following transcatheter aortic valve implantation.Journal of echocardiography · 2026Article
- ILK-Dependent Modulation of DPP4 Prevents Progression of Calcific Aortic Valve Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- The potential role of sex related differences of the microbiome and its impact on calcific aortic stenosis: a narrative review.Biology of sex differences · 2026Review
- Enhanced Recovery After Cardiac Surgery: Gender Insights From an Ultra-Fast-Track Protocol.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Left Ventricular Geometry Improves Prediction of Sex-Specific Post-TAVR Remodeling in Aortic Stenosis.medRxiv : the preprint server for health sciences · 2026Article
- Assessment of Potential Predictors of Aortic Stenosis Severity Using ECG-Gated Multidetector CT in Patients with Bicuspid and Tricuspid Aortic Valves Prior to TAVI.Journal of clinical medicine · 2026Article
- Sex Differences in the Effects of Perioperative Rehabilitation on Postoperative Pulmonary Complications After Cardiac Valve Surgery: A Prespecified Subgroup Analysis of the PORT Randomized Trial.International journal of women's health · 2026Article
- Aortic Stenosis in End-Stage Renal Disease: Incidence, Prevalence, and Mortality in a National Korean Cohort.Journal of clinical medicine · 2025Article
- Long-Term Outcomes in Aortic Stenosis: Mortality Analysis in a Selected Patient Group.Journal of personalized medicine · 2025Article
- Women With Moderate or Severe Aortic Stenosis by Aortic Valve Area Are Disproportionately Classified With Normal-Flow Low-Gradient Aortic Stenosis and Assigned Lower Severity Grades Than Men.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Sex-related differences in patient characteristics, practice patterns and outcomes after bioprosthetic and mechanical aortic valve replacement.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis.Circulation. Cardiovascular imaging · 2025Article
- Surgical and transcatheter aortic valve interventions for aortic stenosis in England: sociodemographic variations in treatment trends and outcome over 20 years.Heart (British Cardiac Society) · 2025Article
- Longitudinal Outcomes of Patients with Aortic Stenosis Stratified by Sex: An Asian Perspective.Journal of cardiovascular development and disease · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Objectives: This review summarizes sex-based differences in aortic stenosis (AS) and identifies knowledge gaps that should be addressed by future studies. Background: AS is the most common valvular heart disease in developed countries. Sex-specific differences have not been fully appreciated, as a result of widespread under diagnosis of AS in women. Summary: Studies including sex-stratified analyses have shown differences in pathophysiology with less calcification and more fibrosis in women's aortic valve. Women have impaired myocardial perfusion reserve and different compensatory response of the left ventricle (LV) to pressure overload, with concentric remodeling and more diffuse fibrosis, in contrast to men with more focal fibrosis and more dilated/eccentrically remodeled LV. There is sex difference in clinical presentation and anatomical characteristics, with women having more paradoxical low-flow/low-gradient AS, under-diagnosis and severity underestimated, with less referral to aortic valve replacement (AVR) compared to men. The response to therapies is also different: women have more adverse events with surgical AVR and greater survival benefit with transcatheter AVR. After AVR, women would have more favorable LV remodeling, but sex-related differences in changes in myocardial reserve flow need future research. Conclusions: Investigation into these described sex-related differences in AS offers potential utility for improving prevention and treatment of AS in women and men. To better understand sex-based differences in pathophysiology, clinical presentation, and response to therapies, sex-specific critical knowledge gaps should be addressed in future research for sex-specific personalized medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.