Evidence map›Paper›PMID 36329948›Full record

ArticleRSC advances2022

Concise two-step chemical synthesis of molnupiravir.

Vinícius R D Pereira, Marco A M Bezerra, Mauro R B P Gomez, Guilherme M Martins, Adilson D da Silva, Kleber T de Oliveira, Rodrigo O M A de Souza, Giovanni W Amarante

Abstract read
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In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Divergent sustainability profiles of molnupiravir synthesis routes are governed by solvent use and process design.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vinícius R D PereiraDepartment of Chemistry, Federal University of Juiz de Fora Campus Martelos Juiz de Fora Minas Gerais 36036-900 Brazil giovanni.amarante@ufjf.edu.br.
Marco A M BezerraChemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro 22041-909 Brazil.
Mauro R B P GomezChemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro 22041-909 Brazil.
Guilherme M MartinsDepartment of Chemistry, Federal University of São Carlos Campus São Carlos, São Carlos São Paulo 13565-905 Brazil.ORCID https://orcid.org/0000-0002-0493-1270
Adilson D da SilvaDepartment of Chemistry, Federal University of Juiz de Fora Campus Martelos Juiz de Fora Minas Gerais 36036-900 Brazil giovanni.amarante@ufjf.edu.br.
Kleber T de OliveiraDepartment of Chemistry, Federal University of São Carlos Campus São Carlos, São Carlos São Paulo 13565-905 Brazil.ORCID https://orcid.org/0000-0002-9131-4800
Rodrigo O M A de SouzaChemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro 22041-909 Brazil.ORCID https://orcid.org/0000-0002-6422-4025
Giovanni W AmaranteDepartment of Chemistry, Federal University of Juiz de Fora Campus Martelos Juiz de Fora Minas Gerais 36036-900 Brazil giovanni.amarante@ufjf.edu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.

Identifiers

PMID36329948
PMCPMC9585438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.