Evidence map›Paper›PMID 36329880›Full record

ArticleJournal of mathematical imaging and vision2022

Image Reconstruction in Light-Sheet Microscopy: Spatially Varying Deconvolution and Mixed Noise.

Bogdan Toader, Jérôme Boulanger, Yury Korolev, Martin O Lenz, James Manton, Carola-Bibiane Schönlieb, Leila Mureşan

Open access · hybridAbstract read
In one paragraph

Article in Journal of mathematical imaging and vision, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Bogdan ToaderCambridge Advanced Imaging Centre, University of Cambridge, Anatomy School, Downing Street, Cambridge, CB2 3DY UK.ORCID 0000-0001-5444-2179
Jérôme BoulangerMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH UK.
Yury KorolevDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge, CB3 0WA UK.
Martin O LenzCambridge Advanced Imaging Centre, University of Cambridge, Anatomy School, Downing Street, Cambridge, CB2 3DY UK.
James MantonMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH UK.
Carola-Bibiane SchönliebDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge, CB3 0WA UK.
Leila MureşanCambridge Advanced Imaging Centre, University of Cambridge, Anatomy School, Downing Street, Cambridge, CB2 3DY UK.
University of Cambridge · GBMRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_U105184326MRF_ MRF-113-0001-F-BOULAWellcome Trust
6 · The paper itself

Abstract

We study the problem of deconvolution for light-sheet microscopy, where the data is corrupted by spatially varying blur and a combination of Poisson and Gaussian noise. The spatial variation of the point spread function of a light-sheet microscope is determined by the interaction between the excitation sheet and the detection objective PSF. We introduce a model of the image formation process that incorporates this interaction and we formulate a variational model that accounts for the combination of Poisson and Gaussian noise through a data fidelity term consisting of the infimal convolution of the single noise fidelities, first introduced in L. Calatroni et al. (SIAM J Imaging Sci 10(3):1196-1233, 2017). We establish convergence rates and a discrepancy principle for the infimal convolution fidelity and the inverse problem is solved by applying the primal-dual hybrid gradient (PDHG) algorithm in a novel way. Numerical experiments performed on simulated and real data show superior reconstruction results in comparison with other methods.

Indexed as

DeconvolutionLight-sheet microscopyNumerical methodsPoisson and Gaussian noisePrimal–dual hybrid gradient

Identifiers

PMID36329880
PMCPMC7613773
OpenAlexW3187799716

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.