Evidence map›Paper›PMID 36329822›Full record

ArticleFrontiers in cellular and infection microbiology2022

Antiviral lectin Q-Griffithsin suppresses fungal infection in murine models of vaginal candidiasis.

Henry W Nabeta, Amanda B Lasnik, Joshua L Fuqua, Lin Wang, Lisa C Rohan, Kenneth E Palmer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Review
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  7. Article
  8. Anti-Candidal Marine Natural Products: A Review.Journal of fungi (Basel, Switzerland) · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Henry W NabetaDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville KY, United States.
Amanda B LasnikCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville KY, United States.
Joshua L FuquaCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville KY, United States.
Lin WangInfectious Diseases, Magee-Womens Research Institute, Pittsburgh, PA, United States.
Lisa C RohanInfectious Diseases, Magee-Womens Research Institute, Pittsburgh, PA, United States.
Kenneth E PalmerDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville KY, United States.
University of Louisville · USMagee-Womens Research Institute · USUniversity of Pittsburgh · US

Funding

Project 3: PREVENT: A first-in-human clinical trial of Griffithsin, an HIV entryU19AI113182 · NIAID · UNIVERSITY OF LOUISVILLE · PI BRAND, RHONDA METTER · 2014 to 2018
$14.8M
The ExCITE Program: Expediting Commercialization, Innovation, Translation, & EntrepreneurshipU01HL127518 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BATES, PAULA J., MILLER, DONALD M. · 2015 to 2017
$3.0M
Antiviral lectins as microbicidesR01AI076169 · NIAID · UNIVERSITY OF LOUISVILLE · PI PALMER, KENNETH E · 2008 to 2011
$2.3M
NHLBI NIH HHS U01 HL127518NIAID NIH HHS R01 AI076169NIAID NIH HHS U19 AI113182
6 · The paper itself

Abstract

Resistance to antifungal agents in vulvovaginal candidiasis has resulted in increasing morbidity among women globally. It is therefore crucial that new antimycotic agents are developed to counter this rising challenge. Q-Griffithsin (Q-GRFT) is a red algal lectin, manufactured in

Indexed as

Anti-Infective Agents, LocalCandidiasis, VulvovaginalHIV-1AnimalsAntiviral AgentsDisease Models, AnimalFemaleHerpesvirus 2, HumanHumansLectinsMicePlant LectinsRecombinant ProteinsAnti-Infective Agents, LocalAntiviral AgentsLectinsPlant Lectinsq-griffithsinRecombinant ProteinsantifungalcandidiasisGriffithsinlectinsQ-Griffithsinvaginal

Identifiers

PMID36329822
PMCPMC9623022
OpenAlexW4306672622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.