ArticlePNAS nexus2022
Socioeconomic disadvantage, chronic stress, and proinflammatory phenotype: an integrative data analysis across the lifecourse.
Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Associations between parental history of dementia and plasma markers of inflammation in a multi-ethnic middle-aged community of adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Impact of socioeconomic deprivation on risk and disease activity of Sjögren's disease.RMD open · 2026Article
- Social Determinants of Health and Risk of Mortality in Adults with Gout or Hyperuricemia: Insights from the 1999-2018 NHANES.Balkan medical journal · 2026Article
- Understanding Cancer Health Disparities.Cancers · 2026Review
- Neighborhood-level disadvantage and lifestyle-based supportive care in head and neck cancer: insights from the Midwestern United States.Academia oncology · 2026Article
- Chronic Disease Prevalence and Modifiable Risk Factors Among Undergraduate Students at Ha'il University: A Population-Level Cross-Sectional Study.Risk management and healthcare policy · 2026Article
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- Life-course socioeconomic position and the gut microbiome in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).Gut microbes · 2025Article
- Joint associations of pre-diabetes, pre-hypertension, and pre-dyslipidemia with cardiovascular and metabolic disease progression.Diabetology & metabolic syndrome · 2025Article
- Narrating the psychoneuroimmunomodulatory properties of serotonin 5-HTActa neuropsychiatrica · 2025Review
- Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents.Brain, behavior, and immunity · 2025Article
- Anti-aging protein α-Klotho is potential for reducing comorbidity risk of cardiometabolic diseases in vulnerable populations and enhancing long-term prognosis.Scientific reports · 2025Article
- Preliminary Evidence of Higher Production of LPS-induced Proinflammatory Cytokines in Retired Versus Employed Dementia Caregivers.Biopsychosocial science and medicine · 2025Article
- Article
- Chronic stress and adiposity in youth-parent dyads: An actor-partner interdependence analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- An Extension to the stress-buffering model: Timing of support across the lifecourse.Brain, behavior, & immunity - health · 2024Article
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Socioeconomic Disadvantage, Neighborhood Belonging, and Inflammation Among Adolescents.Psychosomatic medicine · 2024Article
- Ambient PMEnvironmental research · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Socioeconomic disadvantage confers risk for many chronic illnesses, and theories have highlighted chronic psychological stress and alterations to inflammatory processes as key pathways. Specifically, disadvantage can heighten chronic stress, which may promote a proinflammatory phenotype characterized by immune cells mounting exaggerated cytokine responses to challenge and being less sensitive to inhibitory signals. Importantly, lifecourse perspectives emphasize that such immune alterations should be more potent earlier in life during a sensitive period when bodily tissues are highly plastic to environmental inputs. However, examining these propositions is resource intensive, as they require cell-culturing approaches to model functional inflammatory activities, a wide age range, and longitudinal data. Here, we integrated data from five independent studies to create a diverse sample of 1,607 individuals (960 with longitudinal data; 8 to 64 years old; 359 Asian, 205 Black, and 151 Latino/a). Leveraging the resulting lifecourse data, rich interview assessments of disadvantage and stress, and ex vivo assessments of inflammation, we examined two questions: (1) Does chronic stress account for the link between disadvantage and proinflammatory phenotype? (2) Is there a developmental period during which inflammatory responses are more sensitive to disadvantage and chronic stress? Disadvantage was associated with higher chronic stress, which was linked with a proinflammatory phenotype cross-sectionally, longitudinally, and in terms of prospective change across 1.5 to 2 years. Consistent with the sensitive period hypothesis, the magnitude of these indirect associations was strongest in earlier decades and declined across the lifecourse. These findings highlight the importance of taking a lifecourse perspective in examining health disparities.
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