Evidence map›Paper›PMID 36329627›Full record

ArticlePediatric transplantation2023

Can non-directed living liver donation help improve access to grafts and correct socioeconomic disparities in pediatric liver transplantation?

Dor Yoeli, Amy G Feldman, Rashikh A Choudhury, Hunter B Moore, Shikha S Sundaram, Trevor L Nydam, Michael E Wachs, Elizabeth A Pomfret, Megan A Adams, Whitney E Jackson

Abstract read
In one paragraph

Article in Pediatric transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dor YoeliDivision of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0001-6993-255X
Amy G FeldmanDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatric Medicine, The Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-4021-5615
Rashikh A ChoudhuryDivision of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-3325-3090
Hunter B MooreDivision of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-5939-3828
Shikha S SundaramDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatric Medicine, The Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Trevor L NydamDivision of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Michael E WachsDivision of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Elizabeth A PomfretDivision of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Megan A AdamsDivision of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-0148-1593
Whitney E JacksonDivision of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.

Funding

NRSA Training CoreTL1TR002533 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CICUTTO, LISA · 2018 to 2022
$3.0M
Improving Immunization Rates in Transplant Candidates Through the Use of a Health Information Technology ToolK08HS026510 · AHRQ · UNIVERSITY OF COLORADO DENVER · PI FELDMAN, AMY · 2019 to 2023
$742k
AHRQ HHS K08 HS026510NCATS NIH HHS TL1 TR002533
6 · The paper itself

Abstract

backgroundEach year, children die awaiting LT as the demand for grafts exceeds the available supply. Candidates with public health insurance are significantly less likely to undergo both deceased donor LT and D-LLD LT. ND-LLD is another option to gain access to a graft. The aim of this study was to evaluate if recipient insurance type is associated with likelihood of D-LLD versus ND-LLD LT.

methodsThe SRTR/OPTN database was reviewed for pediatric LDLT performed between January 1, 2014 (Medicaid expansion era) and December 31, 2019 at centers that performed ≥1 ND-LLD LDLT during the study period. A multivariable logistic regression was performed to assess relationship between type of living donor (directed vs. non-directed) and recipient insurance.

resultsOf 299 pediatric LDLT, 46 (15%) were from ND-LLD performed at 18 transplant centers. Fifty-nine percent of ND-LLD recipients had public insurance in comparison to 40% of D-LLD recipients (p = .02). Public insurance was associated with greater odds of ND-LLD in comparison to D-LLD upon multivariable logistic regression (OR 2.37, 95% CI 1.23-4.58, p = .01).

conclusionsND-LLD allows additional children to receive LTs and may help address some of the socioeconomic disparity in pediatric LDLT, but currently account for only a minority of LDLT and are only performed at a few institutions. Initiatives to improve access to both D-LLD and ND-LLD transplants are needed.

Indexed as

Liver TransplantationChildGraft SurvivalHumansLiverLiving DonorsRetrospective StudiesRisk AssessmentSocioeconomic Disparities in HealthTreatment Outcomeliver transplantationliving donor

Identifiers

PMID36329627
PMCPMC10132215

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.