Evidence map›Paper›PMID 36329585›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Hydroxynitone suppresses hepatic stellate cell activation by inhibiting TGF-β1 phosphorylation to alleviate CCl

Z Zhao, H Dong, B Li, B Shen, Y Guo, T Gu, Y Qu, X Cai, L Lu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
  3. [Effects of M2-type macrophages and GKT137831 on oxidative stress in hepatic stellate cells].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Z ZhaoDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
H DongDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
B LiDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
B ShenDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
Y GuoDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
T GuDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
Y QuDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
X CaiDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
L LuDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
Shanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of hydronidone on CCl

methodsSixty-six male SD rats were randomized into 5 groups, including a control group (

resultsIn the rat models of liver fibrosis, treatment with hydronidone obviously improved the liver functions, reduced the content of hydroxyproline in the liver tissue, and significantly alleviated liver fibrosis (

conclusionHydronidone can inhibit the phosphorylation of the proteins in the TGF-β signaling pathway, thereby preventing TGF-β1-mediated activation of hepatic stellate cells, which may be a possible mechanism by which hydronidone alleviates CCl

Indexed as

Hepatic Stellate CellsTransforming Growth Factor beta1AnimalsCarbon TetrachlorideCollagen Type IHydroxyprolineLiver CirrhosisMalePhosphorylationProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionSmad ProteinsCarbon TetrachlorideCollagen Type IHydroxyprolineProto-Oncogene Proteins c-aktSmad ProteinsTransforming Growth Factor beta1hepatic stellate cellshydronidoneliver fibrosistransforming growth factor β1

Identifiers

PMID36329585
PMCPMC9637497
OpenAlexW4308639453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.