Evidence map›Paper›PMID 36329582›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Long-term low-dose microcystin-LR exposure induces renal injury in mice by activating PI3K/AKT signaling pathway].

X Liang, Y Yang, S Xu, Y Liu, H Chu, Y Tang, F Yang

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

X LiangSchool of Public Health, University of South China, Hunan Provincial Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China.
Y YangSchool of Public Health, Central South University, Changsha 410000, China.
S XuWuzhong District Center for Disease Control and Prevention, Suzhou 215100, China.
Y LiuSchool of Public Health, University of South China, Hunan Provincial Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China.
H ChuSchool of Public Health, University of South China, Hunan Provincial Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China.
Y TangSchool of Public Health, University of South China, Hunan Provincial Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China.
F YangSchool of Public Health, University of South China, Hunan Provincial Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China.
University of South China · CNCentral South University · CNChinese Center For Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the toxic effect of long-term low-dose exposure to microcystin-LR (MC-LR) on kidney and its underlying molecular mechanism.

methodsForty male C57BL/6 mice were randomized into 4 groups for exposure to 0, 1, 60, and 120 μg/L MC-LR (mixed in drinking water) for 12 months, and the body and kidney weight changes and renal pathologies of the mice were observed. The renal function indexes, the mRNA expression levels of IL-6, TNF-α and IL-10, and relative expression levels of PI3K/AKT pathway proteins in the kidney of the mice were detected. These parameters were also detected in HEK293 cells treated with MC- LR, LY294002, or both.

resultsThe overall trend of body weight changes was consistent among the 4 groups of mice, and their kidney mass and kidney index underwent no significant changes. In mice exposed to 60 and 120 μg/L MC-LR, obvious renal structural damage and significant elevation of the BUN and SCr levels were observed (

conclusionMC- LR can activate inflammatory response and induce renal structural and functional damages in mice by activating the PI3K/AKT signaling pathway.

Indexed as

Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsHEK293 CellsInterleukin-10Interleukin-6KidneyMaleMarine ToxinsMiceMice, Inbred C57BLMicrocystinsRNA, MessengerSignal TransductionTumor Necrosis Factor-alphacyanoginosin LRInterleukin-10Interleukin-6Marine ToxinsMicrocystinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerTumor Necrosis Factor-alphainflammationkidney damagemicrocystin-LRPI3K/AKT signaling pathway

Identifiers

PMID36329582
PMCPMC9637505
OpenAlexW4308639234

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.