Evidence map›Paper›PMID 36329578›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[

J Liu, W Shen, H Cheng, M Fan, J Xiao, C Xu, J Tan, Y Lai, C Yu, D Sun and 1 more

Open access · greenAbstract readEnglish Abstract
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

J LiuFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
W ShenFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
H ChengFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
M FanFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
J XiaoJiangsu Province Hospital of Chinese Medicine, Nanjing, 210004, China.
C XuFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
J TanFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Y LaiFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
C YuFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
D SunFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
L LiFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Nanjing University of Chinese Medicine · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the inhibitory effect of

methodsFour-week-old male C57BL/6 mice were randomly divided into control group (

resultsCompared with those in the model group, the mice treated with SBJDF, especially at the high dose, showed a significantly lower incidence of intestinal carcinogenesis and had fewer intestinal tumors with smaller tumor volume. Pathological examination showed the occurrence of adenocarcinoma in the model group, while only low-grade and high-grade neoplasia were found in low-dose SBJDF group; the mice treated with high-dose SBJDF showed mainly normal mucosal tissues in the intestines with only a few lesions of low-grade neoplasia of adenoma. Compared with those in the control group, the mice in the model group had significantly elevated plasma miRNA-222 level (

conclusionSBJDF can significantly inhibit colorectal adenoma formation and carcino-genesis in mice possibly through regulating miRNA-222 and affecting PTEN/PI3K/AKT signaling pathway.

Indexed as

AdenomaCarcinogenesisColorectal NeoplasmsDrugs, Chinese HerbalAnimalsAzoxymethaneDextran SulfateDisease Models, AnimalGlycogen Synthase Kinase 3 betaMaleMiceMice, Inbred C57BLMicroRNAsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseAzoxymethaneDextran SulfateDrugs, Chinese HerbalGlycogen Synthase Kinase 3 betaMicroRNAsMIRN222 microRNA, mouseMirn22 microRNA, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePten protein, mouseAOM/DSS murine modecarcinogenesiscolorectal adenomamiRNA-222PTEN/PI3K/AKT signaling pathwayShenbai Jiedu Fang

Identifiers

PMID36329578
PMCPMC9637489
OpenAlexW4308637226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.