Evidence map›Paper›PMID 36329577›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[CircPCSK5 is highly expressed in gastric cancer and promotes cancer cell proliferation, invasion and epithelial-mesenchymal transition].

X Zuo, J Cai, Z Chen, Y Li, D Zhang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [High expression of RAB7A is associated with poor prognosis of gastric cancer by promoting tumor invasion].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

X ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital (Yijishan Hospital) of Wannan Medical College, Wuhu 241001, China.
J CaiKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, First Affiliated Hospital (Yijishan Hospital) of Wannan Medical College, Wuhu 241001, China.
Z ChenHepatobiliary Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Y LiDepartment of Gastrointestinal Surgery, First Affiliated Hospital (Yijishan Hospital) of Wannan Medical College, Wuhu 241001, China.
D ZhangDepartment of Gastrointestinal Surgery, First Affiliated Hospital (Yijishan Hospital) of Wannan Medical College, Wuhu 241001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression of circPCSK5 in gastric cancer (GC) and its role in regulation of the proliferation, invasion and epithelial-mesenchymal transition (EMT) of GC cells.

methodsHigh-throughput sequencing was performed in 3 pairs of GC and adjacent gastric mucosa tissues to obtain the differential expression profile of circRNA. The expression of circPCSK5 was detected in 62 patients undergoing radical surgery for GC using RT-qPCR, and the correlation between circPCSK5 expression level and clinicopathological data of the patients was analyzed. The overall survival and disease-free survival of the patients were assessed with Kaplan-Meier survival analysis, and the independent risk factors affecting the patients' prognosis were analyzed using Cox proportional hazards regression model. The stability and subcellular localization of circPCSK5 were assessed using RNase R and actinomycin D assays, fluorescence

resultsThe expression of circPCSK5 was significantly upregulated in GC tissues and cells (

conclusionCircPCSK5 is highly expressed in GC and promotes the proliferation, invasion and EMT of GC cells, suggesting its potential as a prognostic biomarker and therapeutic target for GC.

Indexed as

Epithelial-Mesenchymal TransitionStomach NeoplasmsCadherinsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansIn Situ Hybridization, FluorescenceNeoplasm InvasivenessVimentinCadherinsVimentincircular RNAepithelial-mesenchymal transitiongastric cancerinvasionprognosisproliferation

Identifiers

PMID36329577
PMCPMC9637502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.